【摘要】 非酒精性脂肪性肝病（NAFLD）是一种涵盖单纯脂肪变性至非酒精性脂肪性肝炎，并可能进一步进展为肝纤维化和肝硬化的常见肝脏疾病。铁死亡是一种依赖铁离子蓄积和脂质过氧化驱动的独特细胞死亡形式，在NAFLD的发生和发展中发挥关键作用。核转录因子红系2相关因子2(Nrf2)是调控氧化还原稳态和铁代谢的核心转录因子，对铁死亡过程具有重要影响。本文系统综述铁死亡的病理机制、Nrf2对铁死亡的调控作用及其介导铁死亡在NAFLD治疗中的潜在应用，深入探讨Nrf2的靶基因在调控铁死亡和NAFLD病程中的作用，评估其作为治疗靶点的可行性，为NAFLD的干预提供理论依据和新思路。更多还原

【Abstract】 Non-alcoholic fatty liver disease(NAFLD) is a common liver disease that ranges from simple steatosis to non-alcoholic steatohepatitis, and may further progress to liver fibrosis and cirrhosis. Ferroptosis is a unique form of cell death driven by iron ion accumulation and lipid peroxidation, which plays a key role in the occurrence and development of NAFLD. Nuclear factor-erythroid 2-related factor 2(Nrf2) is a core transcription factor that regulates redox homeostasis and iron metabolism, and has a significant impact on the process of ferroptosis. This article systematically summarizes pathological mechanism of ferroptosis, regulatory role of Nrf2 in ferroptosis, and its potential application in the treatment of NAFLD, deeply explores the role of Nrf2 target genes in regulating ferroptosis and the course of NAFLD, evaluates feasibility as therapeutic targets, provides theoretical basis and new ideas for the intervention of NAFLD.更多还原