【摘要】 由脓毒症引起的弥漫性脑功能障碍被称为脓毒症相关性脑病（SAE），是脓毒症的一种常见并发症。SAE的发病机制较复杂，目前尚不明确，近年来已取得显著进展，发现SAE与促炎性细胞因子激活、血-脑屏障功能障碍、小胶质细胞和星形胶质细胞激活等多种因素有关。本文对儿童SAE发病机制的研究进展进行综述，以期为SAE患儿的治疗提供更好的策略。更多还原

【Abstract】 Diffuse brain dysfunction caused by sepsis is known as sepsis-associated encephalopathy(SAE), and is a common complication of sepsis. Pathogenesis of SAE is complex, and currently unclear. In recent years, significant progress has been made, and it has been found that SAE is related to various factors such as activation of proinflammatory cytokine,dysfunction of blood-brain barrier, activation of microglia and astrocytes. This article reviews research progress on pathogenesis of SAE in children, in order to provide better strategies for the treatment of SAE in children.更多还原