【摘要】 近年来，国产放射治疗设备研发取得突破性进展，以集成化、智能化为特征的创新放射治疗系统已实现关键技术创新，其核心参数及创新功能模块，如扇形束CT引导的在线自适应放射治疗、多模态影像实时融合技术等均达到国际主流设备水平。但在适应证选择、质量控制标准建立和个性化治疗方案优化等方面尚无统一的标准。为此，在国家重点研发计划项目的支持下，中国医学装备协会放射治疗装备技术分会组织相关领域专家，以高发肿瘤——鼻咽癌为示范病种共同制定本指南，旨在规范国产放射治疗设备在中枢神经系统肿瘤和头颈部肿瘤中的临床应用，推动技术发展与临床协作。针对传统固定计划的放射治疗面临靶区覆盖不足或正常组织过量照射的风险这一临床难点问题，本指南基于国产一体化CT直线加速器的技术优势，在扇形束CT图像引导放射治疗基础上发展起来的在线自适应放射治疗，结合理论与实践，创新性提出在线自适应放射治疗鼻咽癌的临床实施规范，助推精准治疗理念向临床实践转化，实现国产创新一体化放射治疗设备在中枢神经系统肿瘤和头颈部肿瘤的规范化及精准化的应用。更多还原

【Abstract】 In recent years, the research and development of domestic radiotherapy equipment have achieved groundbreaking progress, and the innovative radiotherapy system with integrated and intelligent characteristics has realized innovation of key technique, which coral parameters and innovatively functional models, such as sector beam computed tomography(CT)-guided online self-adaptive radiotherapy, multimodal imaging real-time fusion technique, have achieved internationally mainstream equipment level. However, there are not still unified standard on a series of aspects include selection of indications, establishment of quality control standard, optimization of individual treatment schedule, etc. Therefore, Radiotherapy Equipment and Technology Branch of China Association of Medical Equipment organized experts from relative fields to formulate together this guideline, which selected tumor with high incidence-nasopharyngeal carcinoma as demonstration disease, under the support of the National Key Research and Development Program. The target of this study is to standardize the clinical application of domestic radiotherapy equipment in the tumors of central nervous system, head and neck, so as to promote technical development and clinical collaboration. At the same time, aimed at the clinically difficult problems that the radiotherapy of conventionally fixed schedule existed risks of inadequate target coverage and/or excessive exposure on normal tissue, this guideline combined with theory and practice to innovatively formulate the clinical implementation specification of online self-adaptive radiotherapy for nasopharyngeal carcinoma on the basis of the technical advantages of domestically integrated CT linear accelerator, and the online self-adaptive radiotherapy that developed from the basis of sector beam CT-guided radiotherapy. It contributes to promote the transformation from conception to clinical practice for accurate treatment, and to realize the standard and accurate application of domestically innovative integrated radiotherapy equipment in tumors of central nervous system, head and neck.更多还原