【摘要】 目的：比较¹⁸F-氟代脱氧葡萄糖（fluorodeoxyglucose,FDG）正电子发射体层成像（positron emission tomography,PET）/计算机体层成像（computed tomography,CT）和⁶⁸Ga-成纤维细胞活化蛋白抑制剂（fibroblast activation protein inhibitor,FAPI）PET/CT在不同类型淋巴瘤诊断中的价值。方法：回顾并分析2020年11月—2022年10月复旦大学附属肿瘤医院于1周内行¹⁸F-FDG和⁶⁸Ga-FAPI PET/CT的淋巴瘤患者的临床、病理学及影像学资料，比较两种显像剂对病灶的检出率，同时比较两组最大标准摄取值(maximum standard uptake value,SUV_max)、肿瘤与肌肉本底比值（target-to-background ratio,TBR）及肿瘤与肝脏本底比值（target-to-liver ratio,TLR）的差异。结果：纳入28例经病理学检查确诊的淋巴瘤患者，共计197个淋巴瘤病灶（其中淋巴结病灶167个、结外病灶30个），¹⁸F-FDG PET/CT检出191个病灶（其中淋巴结病灶161个、结外病灶30个），而⁶⁸Ga-FAPI PET/CT检出病灶98个（其中淋巴结病灶74个、结外病灶24个），¹⁸F-FDG PET/CT的病灶检出率明显高于⁶⁸Ga-FAPI PET/CT；但对于胃肠道浸润，¹⁸F-FDG PET/CT具有更高的假阳性。所有淋巴瘤患者SUV_max-FDG>SUV_max-FAPI,TBR-FDG>TBR-FAPI，差异有统计学意义（14.4 vs 6.5,13.3 vs3.4,P<0.05）。但其中霍奇金淋巴瘤（Hodgkin’s lymphoma,HL）的¹⁸F-FDG PET/CT和⁶⁸Ga-FAPI PET/CT的SUV_max及TBR为12.3 vs 6.5及11.6 vs 5.1（均P>0.05）；惰性淋巴瘤的SUV_max及TBR为10.2 vs 10.9及21.4 vs 5.1（均P>0.05），差异均无统计学意义。所有淋巴瘤患者两种检查的TLR差异均未见明显统计学意义（5.2 vs 5.2,P>0.05）。结论：¹⁸F-FDG PET/CT对淋巴瘤的诊断价值优于⁶⁸Ga-FAPI PET/CT，但是对于HL及惰性淋巴瘤，两者间代谢参数差异无统计学意义，¹⁸F-FDG PET/CT的优势不明显；⁶⁸Ga-FAPI PET/CT对于胃肠道浸润具有更高的诊断准确度。更多还原

【Abstract】 Objective:To compare the value of ¹⁸F-fluorodeoxyglucose （FDG） positron emission tomography （PET）/computer tomography （CT） and ⁶⁸GA-fibroblast activation protein inhibitor （FAPI） PET/CT in the diagnosis of different types of lymphoma.Methods:The clinical,pathological and imaging data of patients with lymphoma who received ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in Fudan University Shanghai Cancer Center within one week from November 2020 to October 2022 were retrospectively analyzed,and the detection rates of the two imaging agents for lesions were compared.At the same time,the differences of maximum standard uptake value (SUV_max),target-to-background ratio （TBR） and target-to-liver ratio （TLR） between the two groups were compared.Results:A total of 197 lymphomas （167 lymph node lesions and 30 extranodal lesions） were detected in 28 patients with pathologically confirmed lymphoma,and 191 lesions （161 lymph node lesions and 30 extranodal lesions） were detected by ¹⁸F-FDG PET/CT.⁶⁸Ga-FAPI PET/CT detected 98 lesions （including 74 lymph node lesions and 24 extranodal lesions）,and the detection rate of ¹⁸F-FDG PET/CT was significantly higher than that of ⁶⁸Ga-FAPI PET/CT.But for gastrointestinal infiltrating lesions,¹⁸F-FDG PET/CT has a higher false positive rate.In lymphoma patients,SUV_max-FDG>SUV_max-FAPI,TBR-FDG>TBR-FAPI,the difference was statistically significant （14.4 vs 6.5,13.3 vs 3.4,P<0.05）.However,the SUV_max and TBR of Hodgkin’s lymphoma（HL） were 12.3 vs 6.5,11.6 vs 5.1 （P>0.05） and indolent lymphoma 10.2 vs 10.9,21.4 vs 5.1 （P>0.05）,the difference was not statistically significant.There was no significant difference in TLR between the two examinations in all lymphoma patients （5.2 vs5.2,P>0.05）.Conclusion:The diagnostic value of ¹⁸F-FDG PET/CT for lymphoma is better than ⁶⁸Ga-FAPI PET/CT.But for HL and inert lymphoma,there was no significant difference in metabolic parameters between the two groups,and ⁶⁸Ga-FAPI PET/CT has higher diagnostic accuracy for gastrointestinal infiltration.更多还原