【摘要】 目的 探讨胰岛素降解酶（IDE）基因rs11187007位点多态性与孕妇妊娠期糖尿病（GDM）产后6～8周转归的关系。方法 选择2023年1月至2023年6月在佛山市南海区妇幼保健院诊断为GDM的孕妇129例。产后6～8周行口服葡萄糖耐量试验（OGTT），根据结果分为转归失败组（n=40）和转归良好组（n=89）。比较两组的基因型分布、等位基因频率以及临床资料和检测指标的差异，并做二元logistics回归分析。结果 两组的基因型分布均符合Hardy-Weinberg平衡定律（P均>0.05），具有群体代表性。转归良好组的AA,AG基因型占比和A基因频率均高于转归失败组，差异有统计学意义（P均<0.05）。孕中期2h PG和基因位点突变对产后转归有影响，差异有统计学意义（P均<0.05），其余指标差异无统计学意义（P>0.05）。IDE基因rs11187007位点突变和孕中期高水平2h PG是影响GDM患者产后转归失败的危险因素（P均<0.05）。结论 产后6～8周转归结果不同的GDM患者，其IDE基因rs11187007位点存在多态性分布，该基因位点突变可能是影响GDM转归的独立危险因素。更多还原

【Abstract】 Objective To investigate the relationship between rs11187007 locus polymorphism of insulin degrading enzyme(IDE) gene and the outcome of gestational diabetes mellitus(GDM) in 6-8 weeks postpartum. Methods A total of 129 pregnant women diagnosed with GDM from January to June in 2023 at the Nanhai District Maternal and Child Health Hospital in Foshan City were selected. An oral glucose tolerance test(OGTT) was conducted 6～8 weeks postpartum. Based on the results, the women were divided into two groups: the failure outcome group(n=40) and the good outcome group(n=89). The genotype distribution, allele frequency, clinical data, and detection indexes were compared between the two groups, and logistic regression analysis was performed. Results The genotype distribution of both groups adheres to Hardy-Weinberg’s equilibrium law(P>0.05), indicating population representativeness. The proportion of AA and AG genotypes and the frequency of A genes in the group with good conversion, were higher than those in the group with failed conversion, and the differences were statistically significant(P<0.05). PG and gene site mutations at 2 hours during mid pregnancy have an impact on postpartum outcomes, with statistically significant differences(P<0.05), while other indicators show no statistically significant differences(P>0.05). Mutations at rs11187007 locus of the IDE gene and high levels of 2-hour PG in mid pregnancy are risk factors for postpartum outcome failure in GDM patients(all P<0.05). Conclusion The polymorphism of the IDE gene rs11187007 was found in GDM patients with different outcomes at 6～8 weeks postpartum. The mutation of A to G in the IDE gene may be an independent risk factor for the prognosis of GDM.更多还原