【摘要】 目的 探讨两种剂型亮丙瑞林对中枢性性早熟女童血清黄体生成素（LH）、卵泡刺激素（FSH）及游离甲状腺素（FT4）的影响。方法 选取212例在2023年1月至2024年5月由安徽省儿童医院接诊的中枢性性早熟女童为研究对象，按随机数表法分为一个月剂型组（1M）和三个月剂型（3M）组，各106例。1M组每月注射一次亮丙瑞林，3M组每三个月注射一次亮丙瑞林，持续治疗1年，比较两组血清激素水平、青春期发育情况、生长指标、超声生长参数、不良反应发生情况、注射恐惧、年治疗费用情况。结果 治疗后，两组LH,FSH、FT4水平均降低，差异有统计学意义（P<0.05）；两组间LH,FSH、FT4水平比较，差异无统计学意义（P>0.05）。两组间乳房退化/停滞、阴毛生长增加情况比较，差异无统计学意义（P>0.05）。治疗后，两组卵巢容积、乳核面积、最大卵泡直径均降低，差异有统计学意义（P<0.05）；两组间卵巢容积、乳核面积、最大卵泡直径比较，差异无统计学意义（P>0.05）。3M组出现局部硬结的比例低于1M组，差异有统计学意义（P<0.05）；两组无菌性脓肿、假性脑瘤、阴道出血情况比较，差异无统计学意义（P>0.05）。3M组患儿出现注射恐惧及抗拒比例及年治疗费用低于1M组，差异有统计学意义（P<0.05）。结论 两种剂型亮丙瑞林治疗中枢性性早熟疗效相当，三个月剂型更利于长期治疗。更多还原

【Abstract】 Objective To investigate the effects of two dosage forms of leuprolide on serum luteinizing hormone(LH), follicle stimulating hormone(FSH) and free thyroxine(FT4) in girls with central precocious puberty. Methods A total of 212 girls diagnosed with central precocious puberty were admitted to Anhui Provincial Children,s Hospital from January 2023 to May, 2024 and enrolled in the study. Using the random number table method, they were divided into two groups: a one-month dosage(1M) group and a three-month dosage(3M) group, with 106 cases in each group. The 1M group received monthly injections of leuprorelide, while the 3M group received injections once every three months. Both groups underwent treatment for aduration of one year. The study compared the two groups in terms of serum hormone levels, adolescent development, growth indicators, ultrasonic growth parameters, incidence of adverse reactions, fear of injections, and annual treatment costs. Results After treatment, the levels of LH, FSH, and FT4 in both groups decreased significantly(P<0.05). There were no significant differences in LH, FSH and FT4 levels between the two groups(P>0.05). There was no significant difference in breast regression/stagnation and pubic hair growth between the two groups(P>0.05). After treatment, the ovarian volume, breast nucleus area and maximum follicle diameter in both groups were significantly reduced(P<0.05). There were no significant differences in ovarian volume, breast bud area, and maximum follicle diameter between the two groups(P>0.05). The incidence of local induration in the 3M group was significantly lower than that in the 1M group(P<0.05). There were no significant differences in aseptic absences, pseudotumor cerebri and vaginal bleeding between the two groups(P>0.05). Compared to the 1M group, the 3M group had significantly lower levels of injection fear and resistance, as well as a lower annual treatment cost(P<0.05). Conclusion Both formulations of leuprolide have similar efficacy in treating central precocious puberty. However, the 3-month formulation of leuprolide is more suitable for longterm treatment.更多还原