【摘要】 目的 分析拉贝洛尔与硝苯地平分别联合硫酸镁治疗妊娠期高血压（HDP）患者的效果，并进一步探讨其对患者凝血功能、心肌功能、肾功能的影响。方法 选取2021年1月至2025年3月黄山市人民医院接诊的58例HDP患者作为研究对象，所有患者均给予硫酸镁治疗，并按照随机掷硬币法分对照组（29例，加用硝苯地平）和研究组（29例，加用拉贝洛尔），连续治疗7 d，比较两组治疗效果及治疗前后凝血功能[凝血酶原时间（PT）、D-二聚体（D-D）、纤维蛋白原（Fib）]水平、心肌酶[心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶（CK-MB）]水平、肾损伤指标[24h尿蛋白定量（24h UP）、尿钙黏蛋白（UC）、尿激肽原（UK）]水平，并观察不良反应。结果 研究组总有效率高于对照组，差异有统计学意义（P<0.05）；两组治疗后PT长于治疗前，且研究组长于对照组，差异有统计学意义（P<0.05），两组治疗前后及两组组间的D-D、Fib水平比较，差异均无统计学意义（P>0.05）；研究组治疗后cTnI、CK-MB水平低于治疗前，且研究组低于对照组，差异有统计学意义（P<0.05），对照组治疗前后cTnI、CK-MB水平比较，差异无统计学意义（P>0.05）；两组患者治疗后24h UP、UC、UK水平均低于治疗前，且研究组低于对照组，差异有统计学意义（P<0.05）；两组反射性心动过速等不良反应总发生率比较，差异无统计学意义（P>0.05）。结论 较硝苯地平联合硫酸镁，拉贝洛尔联合硫酸镁治疗HDP患者的效果更好，能延长患者PT，保护患者心肌功能及肾功能，且具备一定安全性。更多还原

【Abstract】 Objective To analyze the effect of labetalol or nifedipine combined with magnesium sulfate on patients with hypertensive disorders of pregnancy(HDP), and further explore the influence on coagulation function, myocardial function and renal function of patients. Methods A total of 58 patients with HDP admitted to Huangshan People’s Hospital from January 2021 to March 2025 were selected as study subjects, and were treated with magnesium sulfate. According to the random coin tossing method, they were divided into control group(29 cases, nifedipine) and study group(29 cases, labetalol), and both groups were continuously treated for 7 days. The therapeutic effect and coagulation function [prothrombin time(PT), D-dimer(D-D), fibrinogen(Fib)], myocardial enzymes [cardiac troponin I(CTnI), creatine kinase isoenzyme(CK-MB)] and renal injury indexes [24-hour urinary protein quantification(24h UP), urinary cadherin(UC), urinary kallikrein(UK)] before and after treatment were compared between groups, and the adverse reactions were observed. Results The total effective rate in study group was higher than that in control group(P<0.05). Compared with before treatment, the PT in the two groups after treatment was longer, and the PT in study group was longer than that in control group(P<0.05), and there were no statistical differences in D-D and Fib levels in the two groups before and after treatment and between groups(P>0.05). After treatment, the levels of CTnI and CK-MB in study group were lower than those before treatment, and the levels were lower compared to control group(P<0.05). However, no statistical differences were found in the levels of CTnI and CK-MB in control group before and after treatment(P>0.05). The 24h UP, UC and UK levels were lower in the two groups after treatment compared with those before treatment, and the levels in study group were lower compared to control group(P<0.05). There was no statistical significance in the total incidence rate of adverse reactions such as reflex tachycardia between the two groups(P>0.05). Conclusion Compared with nifedipine combined with magnesium sulfate, labetalol combined with magnesium sulfate is more effective in the treatment of HDP patients, and it can prolong PT and protect myocardial function and renal function of patients, with certain safety.更多还原