【摘要】 目的 探究血清涎液化糖链抗原（KL-6）表达对社区获得性肺炎（CAP）严重程度的预测价值。方法 选取2022年3月-4月收住在吉林省人民医院的CAP成人患者128例（重症组18例，非重症组110例）。另选性别、年龄与之相匹配的健康体检者128例（健康对照组）。检测并对比三组血清KL-6水平，分析血清KL-6表达与CAP严重程度的关系，采用受试者工作特征曲线（ROC曲线）分析血清KL-6水平对重症CAP的预测价值观察血清KL-6水平作为鉴别重症与非重症的敏感性及特异性。结果 重症组合并肝脏疾病、肾脏疾病、电解质紊乱、脑梗的合并率高于非重症组，差异有统计学意义（P<0.05），而两者合并高血压、糖尿病、心脏病占比比较，差异无统计学意义（P>0.05）。重症组血清KL-6水平高于非重症组、健康对照组，非重症患者组血清KL-6水平高于健康对照组（P<0.05）。ROC分析可知，曲线下面积（AUC）为92.20%,95%CI(0.920,0.924),P=0.000，最佳临界值为439 U/ml，敏感性为99.00%，特异性为82.10%。结论 血清KL-6水平与CAP严重程度有关，对早期预测重症CAP具有重要的参考价值，值得临床应用。更多还原

【Abstract】 Objective To explore the predictive value of Krebs von den Lungen 6(KL-6) expression for the severity of community-acquired pneumonia(CAP). Methods A total of 128 adult patients with CAP(18 patients in the severe group and 110 patients in the non-severe group)admitted to Jilin Provincial People’s Hospital from March to April 2022 were selected. Another 128 healthy subjects(healthy control group) with matching gender and age were selected. The serum KL-6 levels of the three groups were detected and compared, and the relationship between serum KL-6 expression and the severity of CAP was analyzed. The receiver operating characteristic curve(ROC curve) was used to analyze the predictive value of serum KL-6 level for severe CAP. The sensitivity and specificity of serum KL-6 level as a differential diagnosis of severe and non-severe.Results The combined rate of severe group with liver disease, kidney disease, electrolyte disorder and cerebral infarction was higher than that of non-severe group, and the difference was statistically significant(P<0.05), while there was no significant difference in the proportion of hypertension,diabetes, heart disease between the two groups(P>0.05). The serum KL-6 level in severe group was higher than that in non-severe group and healthy control group, and the serum KL-6 level in non-severe group was higher than that in healthy control group( P<0.05). ROC analysis showed that the area under the curve(AUC) was 92.20%, and the 95%CI was(0.920, 0.924), P=0.000. The optimal critical value was 439 U/ml, the sensitivity was99.00%, and the specificity was 82.10%. Conclusion Serum KL-6 level is related to the severity of CAP, which has important reference value for early prediction of severe CAP and is worthy of clinical application.更多还原