【摘要】 目的 了解某高校社区绝经后期女性发生髋关节骨质疏松的影响因素，为早期预防髋关节骨质疏松性骨折提供依据。方法 选择2021年1月-2023年1月在北京交通大学医院体检的362例绝经后期女性为研究对象，采用双能X线骨密度仪（DXA）测量全髋的骨密度，根据骨密度（BMD）的结果分为骨质疏松症组和非骨质疏松症组。观察两组甲状腺激素及性激素指标水平，分析绝经后期女性发生髋关节骨质疏松症的危险因素。结果 362例绝经后期女性中有116例发生了髋关节骨质疏松，髋关节骨质疏松发生率为32.04%(116/362)；绝经年限和体重指数是与髋关节骨质疏松症相关的重要因素；骨质疏松症组和未发生骨质疏松症组的促甲状腺激素（TSH）、雌二醇（E2）水平比较，差异有统计学意义（P<0.05）；不同TSH分组的BMD比较，差异有统计学意义（P<0.05），亚临床甲亢组BMD最低；多因素Logistic回归分析结果显示吸烟、绝经年限、尿酸（UA）、TSH、E2是绝经后期髋关节骨质疏松症的影响因素。结论 绝经后期女性髋关节骨质疏松症需要引起关注，除了双能X线骨密度仪（DXA）、骨质疏松风险评估问卷，TSH与E2水平也可用于评估骨质疏松症发生风险，值得临床应用。更多还原

【Abstract】 Objective To understand the influencing factors of postmenopausal women with hip osteoporosis in a university community, and to provide evidence for early prevention of osteoporotic hip fracture. Methods A total of 362 postmenopausal women who underwent physical examination in Beijing Jiaotong University Hospital from January 2021 to January 2023 were selected as the study subjects. The bone mineral density of the total hip was measured by dual-energy X-ray absorptiometry(DXA). According to the results of bone mineral density(BMD), they were divided into osteoporosis group and non-osteoporosis group. The levels of thyroid hormones and sex hormones in the two groups were observed, and the risk factors of hip osteoporosis in postmenopausal women were analyzed. Results Among the 362 postmenopausal women, 116 had hip osteoporosis, and the incidence of hip osteoporosis was 32.04%(116/362). Menopause years and body mass index were important factors associated with hip osteoporosis.There were significant differences in the levels of thyroid stimulating hormone(TSH) and estradiol(E2) between the osteoporosis group and the nonosteoporosis group(P <0.05). There was significant difference in BMD among different TSH groups(P <0.05), and the BMD of subclinical hyperthyroidism group was the lowest. Multivariate logistic regression analysis showed that smoking, years of menopause, uric acid(UA), TSH and E2were the influencing factors of hip osteoporosis in postmenopausal women. Conclusion Hip osteoporosis in postmenopausal women needs our attention.In addition to dual-energy X-ray absorptiometry(DXA) and osteoporosis risk assessment questionnaire, TSH and E2levels can also be used to assess the risk of osteoporosis, which is worthy of clinical application.更多还原