【摘要】 小干扰RNA(si RNA)介导的RNA干扰（RNAi）技术已被广泛研究，但其临床应用仍面临挑战，包括药代动力学性质不佳、易发生酶降解、细胞摄取率低和非特异性基因沉默等问题。开发具有高沉默效率、良好生物相容性且易于功能化的si RNA递送载体，对于推动si RNA疗法的临床转化至关重要。综述了一种极具潜力的非病毒载体——金属有机框架（MOF）在si RNA递送方面的最新研究进展，旨在为高效si RNA递送平台的设计提供思路与参考。更多还原

【Abstract】 Small interfering RNA(siRNA)-mediated RNA interference(RNAi) technology has been extensively studied, but its clinical applications still face challenges, including poor pharmacokinetic properties, susceptibility to enzymatic degradation, low cell uptake rate,and non-specific gene silencing. Developing siRNA delivery vehicles with high silencing efficiency, good biocompatibility, and facile functionalization is crucial for advancing siRNA therapies toward clinical translation. This article reviews the latest research progress on metal-organic frameworks(MOFs) as highly promising non-viral carriers for siRNA delivery, aiming to provide insights and references for the design of efficient siRNA delivery platforms.更多还原