【摘要】 目的 分析2014—2023年山东省菏泽市急性乙型病毒性肝炎(急性乙肝)流行特征，为制定菏泽市乙型肝炎防控方案提供科学依据。方法 利用中国疾病预防控制信息系统，收集菏泽市2014—2023年急性乙肝报告病例资料，分析菏泽市急性乙肝的流行特征，采用率或百分比表示分类变量，χ~2检验进行组间比较。结果 2014—2023年菏泽市急性乙肝病例1 261例，年平均报告发病率为1.46/10万，各年份急性乙肝报告发病率范围为2014年的2.25/10万至2023年的1.01/10万，不同年份急性乙肝报告发病率差异有统计学意义(χ~2=72.085,P<0.001)。菏泽市急性乙肝发病地区集中在曹县、巨野县和牡丹区，占比合计为44.09%，各县区急性乙肝年平均报告发病率差异有统计学意义(χ~2=22.747,P<0.001); 30～<45岁年龄组急性乙肝病例占比最高，为30.93%,0～<15岁年龄组急性乙肝病例占比最低，为2.85%;农民、家务及待业和工人急性乙肝病例占比较高，占比合计为90.01%(1 135/1 261);农民与非农民职业人群急性乙肝报告发病率差异有统计学意义(χ~2=466.179,P<0.001)。结论 2014—2023年菏泽市急性乙肝报告发病率整体呈下降趋势，流行特征无明显季节性，地区差异明显，报告病例中30～<45岁年龄组报告发病率最高，需加强成人乙肝疫苗的免疫接种。更多还原

【Abstract】 Objective To analyze the epidemiological characteristics of acute viral hepatitis B( acute hepatitis B) in Heze City of Shandong Province from 2014 to 2023,and to provide a scientific basis for the development of prevention and control programs for hepatitis B in Heze City. Methods The data on reported cases of acute hepatitis B in Heze City from 2014 to 2023 was collected,using the China disease prevention and control information system to analyze the epidemiological characteristics of acute hepatitis B in Heze City. The rate or percentage was used to represent categorical variable,and the Chi-square test was used for comparison between groups. Results There were 1 261 cases of acute hepatitis B in Heze City from 2014 to 2023,with a mean annual reported incidence rate of 1. 46/100 000. The reported incidence rate of acute hepatitis B for various years ranged from 2. 25/100 000 in 2014 to 1. 01/100 000 in 2023. The difference in the reported incidence rate of acute hepatitis B in different years was statistically significant( χ~2= 72. 085,P<0. 001). The areas of acute hepatitis B incidence in Heze City were concentrated in Cao County,Juye County and Mudan District,accounting for 44. 09% in total. The difference in the mean annual reported incidence rates of acute hepatitis B in various counties and districts was statistically significant( χ~2= 22. 747,P<0. 001). The percentage of acute hepatitis B cases was highest in the age group of 30-<45 years,at 30. 93%. The percentage of acute hepatitis B cases was lowest in the age group of 0-< 15 years,at 2. 85%. The percentage of acute hepatitis B cases was high among farmers,housework,waiting for employment,and workers,accounting for 90. 01%( 1 135/1 261) in total. The difference in the reported incidence rate of acute viral hepatitis B between farmers and non-farmers occupational population was statistically significant( χ~2= 466. 179,P<0. 001).Conclusion From 2014 to 2023,the reported incidence rates of acute hepatitis B in Heze City show an overall downward trend,with no obvious seasonality in epidemiologic characteristics and obvious regional differences. The reported incidence rates of reported cases is the highest in the age group of 30-<45 years. Adult immunization with hepatitis B vaccine immunization should be strengthened.更多还原