【摘要】 目的 分析2019—2023年石家庄市人间布鲁菌病(简称人间布病)的流行特征，为石家庄市制定人间布病防控措施提供参考依据。方法 通过中国疾病预防控制信息系统收集2019—2023年石家庄市人间布病数据资料，采用描述流行病学方法对人间布病的三间分布进行分析，定性资料的比较采用χ~2检验，发病-诊断间隔比较采用Kruskal Wallis秩和检验。结果 2019—2023年石家庄市报告人间布病病例1 599例，人间布病年均发病率为2.86/10万，无死亡病例，不同年份人间布病发病率差异有统计学意义(χ~2=125.55,P<0.001);4—7月为人间布病发病高峰，发病例数占病例总数的51.28%;全市各县(市、区)均有人间布病病例报告；人间布病病例的男女性别比为3.10∶1;人间布病病例发病年龄为10月龄～88岁，主要集中在50～<70岁，占51.78%;人间布病病例的职业以农民为主，占84.37%。人间布病病例的发病-诊断间隔中位数为10d,各年份报告人间布病病例的发病-诊断间隔差异无统计学意义(H=9.15,P=0.057),不同月份报告人间布病病例的发病-诊断间隔差异有统计学意义(H=51.92,P<0.001)。结论 2019—2023年石家庄市人间布病报告病例数呈波动趋势，2021年人间布病形成流行高峰。人间布病病例以中老年男性农民为主。人间布病地区分布广泛，发病呈季节性特征，应在流行季节前做好宣传和防控措施，继续加强人间布病监测和部门联防联控，防止人间布病疫情扩大。更多还原

【Abstract】 Objective To analyze the epidemiological characteristics of human brucellosis in Shijiazhuang City from 2019 to 2023, and to provide a reference basis for the development prevention and control measures of human brucellosis in Shijiazhuang City.Methods Data and information on human brucellosis in Shijiazhuang City were collected from 2019 to 2023 through the China disease control and prevention information system.A descriptive epidemiologic approach to analyze the spatial, temporal and population distribution of human brucellosis.Comparison of qualitative data was performed using the Chi-square test.Onset-diagnostic interval was compared using the Kruskal Wallis rank sum test.Results From 2019 to 2023, a total of 1 599 cases of human brucellosis cases were reported in Shijiazhuang City.The annual mean reported incidence rate of human brucellosis was 2.86/100 000,with no deaths, and the difference in the incidence rate of human brucellosis between different years was statistically significant(χ~2=125.55,P<0.001).The peak of onset of human brucellosis was form April to July, when the number of cases of onset of disease accounted for 51.28% of the total number of cases.Cases of human brucellosis were reported in all counties(cities and districts) of the city.The gender ratio of male to female of human brucellosis cases was 3.10∶1.The age of onset of human brucellosis cases ranged 10 months to 88 years old, mainly concentrated in age from 50-<70 years old, accounting for 51.78%.The occupation of human brucellosis cases was mainly farmers, accounting for 84.37%.The median onset-diagnostic interval of human brucellosis cases was 10 days.The difference in onset-diagnostic interval of reported cases of human brucellosis in various years was not statistically significant(H=9.15,P=0.057).The difference in onset-diagnostic interval of reported cases of human brucellosis in different months was statistically significant(H=51.92,P<0.001).Conclusion The number of reported cases of human brucellosis shows a fluctuating trend in Shijiazhuang City from 2019 to 2023.Human brucellosis reaches an epidemic peak in 2021.The cases of human brucellosis are mainly middle-aged and elderly male farmers.The regional distribution of human brucellosis is widespread, and the onset of the disease is characterized by seasonality.It should carry out publicity and prevention and control measures well in advance of the epidemic season, and continue to strengthen the surveillance of human brucellosis and sectoral joint prevention and control, so as to prevent the expansion of the epidemic of human brucellosis.更多还原