【摘要】 目的 分析半夏白术天麻汤对高血压伴心力衰竭(痰湿内阻证)患者心率变异性及血清爱帕琳肽(Apelin)、心肌营养素-1(CT-1)、内皮素-1(ET-1)水平的影响。方法 选取2022年5月至2024年7月南阳市中心医院收治的高血压伴心力衰竭(痰湿内阻证)患者162例，随机分为对照组(81例)与试验组(81例)。对照组予以常规治疗，试验组在常规治疗基础上联合半夏白术天麻汤治疗，两组均治疗12周。比较两组治疗12周后的临床疗效，治疗前、治疗12周后血清Apelin、CT-1、ET-1水平，心率变异性、心功能指标以及血压，记录两组不良反应情况。结果 治疗12周后，试验组总有效率(95.06%)高于对照组(81.48%)(P<0.05)；试验组血清CT-1、ET-1水平低于对照组，血清Apelin水平高于对照组(P<0.05)；试验组心率变异性各项指标高于对照组(P<0.05)；试验组左心室射血分数(LVEF)、舒张早期及末期血流速度峰值比值(E/A)高于对照组(P<0.05)；试验组心室后壁厚度(LVPW)、室间隔厚度(IVS)水平低于对照组(P<0.05)；试验组24 h收缩压变异系数(SBPcv)、24 h舒张压变异系数(DBPcv)、收缩压(SBP)、舒张压(DBP)水平低于对照组(P<0.05)。两组治疗期间均未出现相关不良反应。结论 在常规治疗的基础上，应用半夏白术天麻汤治疗高血压伴心力衰竭(痰湿内阻证)患者效果确切，可调节血清Apelin、CT-1、ET-1水平，改善患者心率变异性、血压及心功能，安全性良好。更多还原

【Abstract】 Objective To analyze the effects of banxia baizhu tianma decoction on heart rate variability and serum levels of Apelin,myocardial nutrient 1 (CT-1) and endothelin-1 (ET-1) in patients with hypertension and heart failure (phlegm-dampness internal obstruction syndrome).Methods From May 2022 to July 2024,162 patients with hypertension and heart failure (phlegm-dampness internal obstruction syndrome) admitted to Nanyang Central Hospital of were randomly divided into the control group (81 cases) and the experimental group (81 cases).The control group was given conventional treatment,and on this basis,the experimental group was treated with banxia baizhu tianma decoction,treatment period was 12 weeks.The clinical efficacy after 12 weeks of treatment,serum levels of Apelin,CT-1 and ET-1,heart rate variability,cardiac function index and blood pressure before and after 12 weeks of treatment were compared between the two groups,record the adverse reaction conditions of the two groups.Results After 12 weeks of treatment,the total effective rate of the experimental group (95.06%) was higher than that of the control group (81.48%) (P<0.05).The levels of serum CT-1 and ET-1 in the experimental group were lower than those in the control group,the serum Apelin level in the experimental group was higher than that in the control group (P<0.05).The heart rate variability indicators of the experimental group were higher than those of the control group (P<0.05).The left ventricular ejection fraction (LVEF) and the ratio of peak blood flow velocity in early diastole to late diastole (E/A) in the experimental group were higher than those in the control group (P<0.05).The levels of posterior ventricular wall thickness (LVPW) and ventricular septal thickness (IVS) in the experimental group were lower than those in the control group (P<0.05).The levels of 24-hour systolic blood pressure variation coefficient (SBPcv),24-hour diastolic blood pressure variation coefficient (DBPcv),systolic blood pressure (SBP),and diastolic blood pressure (DBP) in the experimental group were lower than those in the control group (P<0.05).No related adverse reactions occurred during the treatment period.Conclusion On the basis of conventional treatment,banxia baizhu tianma decoction was effective in the treatment of patients with hypertension and heart failure (phlegm-dampness internal obstruction syndrome),which could regulate the levels of serum Apelin,CT-1 and ET-1,and improve the heart rate variability,blood pressure and heart function of patients.更多还原