【摘要】 为探讨反复呼吸道感染(RRTIs)患儿与健康儿童的维生素D差异及其临床意义，选取诊断为RRTIs的患儿100例为疾病组，同时选取正常儿童100例为对照组，依据年龄将研究对象分为0～3岁组、3～6岁组、6～14岁组.采集RRTIs患儿与正常儿童的血液标本，应用高效液相色谱—串联质谱技术检测其血清25-(OH)D含量.结果表明，RRTIs患儿25-(OH)D水平低于对照组(P<0.05),尤其3～6岁时疾病组与对照组差异极显著(P<0.01);RRTIs患儿维生素D不足的占比显著高于对照组(P<0.01);对照组中血清25-(OH)D水平随年龄增长进行性下降，差异有统计学意义(P<0.01);RRTIs组中血清25-(OH)D水平随年龄增长逐渐下降，但3～6岁组与6～14岁组血清25-(OH)D水平无显著差异.以上结果说明，RRTIs患儿多伴有维生素D下降，尤其3～6岁RRTIs患儿下降明显，儿童随年龄增长维生素D水平逐渐降低，积极补充维生素D有助于治疗RRTIs.更多还原

【Abstract】 In order to compare the levels of vitamin D between children with recurrent respiratory tract infections(RRTIs) and healthy children, a total of 100 children with RRTIs were enrolled as the disease group, while 100 healthy children were enrolled as the control group.According to the age all children were divided into 0～3 years old group, 3～6 years old group and 6～14 years old group.Blood specimens were collected.And the content of 25-(OH) D was detected by high-performance liquid chromatography tandem masss pectrometry technology.The results showed that the content of 25-(OH) D in the disease group was less than that in the control group(P<0.05);Especially the 3～6 years old group, the difference was very significant(P<0.01); The children with RRTIs had a higher proportion of vitamin D deficiency(P<0.01);The levels of 25-(OH) D in the control group gradually decreased with age(P<0.01); The levels of 25-(OH) D in the RRTIs group decreased with age, but there were no differences in levels of 25-(OH) D between the 3～6 years old group and the 6～14 years old group.In conclusion, Children with RRTIs have low levels of vitamin D,especially the 3～6 years old group.The levels of vitamin D gradually decrease with age, and supplementing with vitamin D may support to treat RRTIs.更多还原