【摘要】 “先同步后分步”是药物化学实验教学的创新模式，以2-氨基-噻唑乙酸制备为案例，突破传统教学局限。该模式前期将微通道反应器操作训练与理论讲解同步，以硫脲、4-氯乙酰乙酸乙酯为原料，经四丁基溴化铵催化，同步完成环合、水解、酸化制得2-氨基-4-乙酸乙酯；后期分步实现中间体氢氧化钠水解与pH调控析产。其依托微通道技术，具收率高、操作简、结果稳优势，深化实验广度与深度，助学生掌握技能、了解前沿。但模式对学生理论基础、动手及问题解决能力要求高，也需教师更新知识、转变教学角色。该模式能激发学生探索欲，为药物化学实验教学提供新路径，应用前景广阔。更多还原

【Abstract】 The “synchronization first, then step-by-step” approach is an innovative model for teaching organic chemistry experiments. Taking the preparation of 2-amino-thiazole acetic acid as a case, it breaks through the limitations of traditional teaching. In the early stage, the operation training of the microchannel reactor is synchronized with theoretical explanations. Using thiourea and ethyl 4-chloroacetoacetate as raw materials, and catalyzed by tetrabutylammonium bromide, the cyclization, hydrolysis, and acidification are completed simultaneously to obtain 2-amino-4-ethyl acetoacetate. In the later stage, the hydrolysis of the intermediate with sodium hydroxide and pH regulation for product precipitation are achieved step by step. Relying on microchannel technology, this model has the advantages of high yield, simple operation, and stable results. It deepens the breadth and depth of experiments and helps students master skills and understand the latest developments. However, this model requires a solid theoretical foundation, good hands-o microchanneln skills, and problem-solving abilities from students. It also demands that teachers update their knowledge and transform their teaching roles. This model can stimulate students’ curiosity and provide a new path for organic chemistry experiment teaching, with broad application prospects.更多还原