【摘要】 白介素-33(interleukin-33,IL-33)是白介素-1的超家族成员，是机体炎症的“预警因子”，当细胞坏死或组织损伤时，IL-33被大量释放，与其受体ST2结合形成复合体从而发挥多种生物学效应。在急性肾损伤、梗阻性肾病、糖尿病肾病、IgA肾病、狼疮性肾炎、移植肾等多种肾脏疾病中IL-33/ST2信号通路被激活，通过调节肾脏固有免疫和适应性免疫反应，在炎症及肾脏纤维化中发挥重要作用。本文综述了IL-33/ST2信号在常见肾脏疾病中的研究进展，希望为肾脏疾病的治疗提供新的靶点和思路。更多还原

【Abstract】 Interleukin-33(IL-33) is a member of the interleukin-1 superfamily and a "warning factor" for inflammation in the body. When cells die or tissues are damaged, IL-33 is released in large quantities and binds to its receptor ST2 to form a complex, exerting various biological effects. IL-33/ST2 signaling pathway is activated in many kidney diseases, such as acute renal injury, obstructive nephropathy, diabetes nephropathy, IgA nephropathy,lupus nephritis, and kidney transplantation. It plays an important role in inflammation and renal fibrosis by regulating the intrinsic and adaptive immune responses of the kidney. This article reviews the research progress of IL-33/ST2 signaling in common kidney diseases, hoping to provide new targets and ideas for the treatment of kidney diseases.更多还原