【摘要】 目的 探讨青少年屈光参差患者眼部生物学参数的相关性，为临床防治提供参考依据。方法 选取2022年6月至2024年6月在长治医学院附属和济医院眼科就诊的66例（132眼）屈光参差患者，根据参差量不同将其分为A组（0～<1.00 D）、B组（1.00～<2.00 D）、C组（≥2.00 D）。检测等效球镜度（SE）及双眼等效球镜度差值（SED）、眼轴长度（AL）及双眼眼轴长度差值（ALD）、角膜曲率（K）及双眼角膜曲率差值（KD）。对数据进行正态性检验和Pearson相关性分析，并建立一元线性回归模型。结果 66例（132眼）青少年屈光参差患者中A组40眼，B组52眼，C组40眼。Pearson相关性分析结果显示，三组SE与AL均存在显著相关性（A组、C组相关性较强），仅A组SE与K存在相关性；双眼差值分析结果显示，仅C组SED与ALD存在相关性。一元线性回归分析结果显示，三组SE与AL均存在线性关系，仅A组SE与K存在线性关系；双眼差值分析结果显示，仅C组SED与ALD存在线性关系。结论 青少年屈光参差患者的SE/SED与AL/ALD之间存在显著相关性，而K/KD与SE/SED的相关性较弱；在屈光参差量较低时，K与AL呈现一定的相关性。通过长期监测青少年屈光参差患者眼部生物学参数的动态变化，有望构建屈光参差风险预测模型，这将有助于揭示屈光参差的发展规律并探索新的治疗靶点。更多还原

【Abstract】 Objective To explore the correlation of ocular biological parameters in adolescent patients with anisometropia, and to provide reference for clinical prevention and treatment. Methods A total of 66patients(132 eyes) with anisometropia who were treated in the ophthalmology department of Heji Hospital Affiliated to Changzhi Medical College from June 2022 to June 2024 were selected and divided into group A(0-<1.00 D), group B(1.00-<2.00 D), and group C(≥2.00 D) according to the difference of anisometropia.The spherical equivalent(SE) and its binocular difference(SED), axial length(AL) and its binocular difference(ALD), keratometry(K) and its binocular difference(KD) were measured. Normality test and Pearson correlation analysis were performed on the obtained data, and a linear regression model was established. Results Of the 66 patients(132 eyes) with adolescent anisometropia, 40 eyes were included in the group A, 52 eyes were included in the group B and 40 eyes were included in the group C. Pearson correlation analysis results showed that there was a significant correlation between SE and AL in the three groups(the group A and the group C had a strong correlation), and only SE and K in the group A had a correlation; the results of binocular difference analysis showed that there was a correlation between SED and ALD in the group C only.The results of simple linear regression analysis showed that there was a linear relationship between SE and AL in the three groups, and only SE and K in the group A had a linear relationship; the results of binocular difference analysis showed that only the group C had a linear relationship between SED and ALD. Conclusion In adolescent patients with anisometropia, there is a significant correlation between SE/SED and AL/ALD,while the correlation between K/KD and SE/SED is weaker. When the degree of anisometropia is low, K and AL exhibit a certain correlation. By long-term monitoring of the dynamic changes in ocular biological parameters of adolescent anisometropia patients, it is expected to construct a risk prediction model for anisometropia, which will help to reveal the developmental patterns of anisometropia and explore new therapeutic targets.更多还原