【摘要】 目的 研究左乙拉西坦联合卡马西平治疗高血压脑出血后癫痫患者的临床效果。方法 纳入2021年1月至2023年12月商丘市第一人民医院神经外科收治的100例高血压脑出血后癫痫患者作为研究对象，按照随机数字表法将其分为参照组（50例，卡马西平）和观察组（50例，在参照组基础上给予左乙拉西坦）。比较两组的治疗效果。结果 观察组的治疗总有效率为96.00%，高于参照组的80.00%(P<0.05)。观察组的不良反应总发生率低于参照组（P<0.05）。治疗后，观察组的癫痫发作次数少于参照组，癫痫发作持续时间短于参照组（P<0.05）。治疗后，观察组的S-100β蛋白（S-100β）、神经元特异性烯醇化酶（NSE）水平低于参照组（P<0.05）。治疗后，观察组的白细胞介素-1β(IL-1β)、白细胞介素-2(IL-2)及肿瘤坏死因子-α(TNF-α)水平低于参照组（P<0.05）。治疗后，观察组的脑电图α频段、β频段功率高于参照组，δ频段功率低于参照组（P<0.05）。结论左乙拉西坦联合卡马西平治疗高血压脑出血后癫痫患者的效果显著，不仅可减少癫痫发作次数，还可以改善神经细胞因子与炎症因子，且安全性较高，值得推广。更多还原

【Abstract】 Objective To study the clinical effect of levetiracetam combinded with carbamazepine in the treatment of patients with epilepsy after hypertensive cerebral hemorrhage. Methods A total of 100 patients with epilepsy after hypertensive cerebral hemorrhage admitted in the neurosurgery department of the First People’s Hospital of Shangqiu from January 2021 to December 2023 were included as the research objects.According to the random number table method, the patients were divided into reference group(50 cases,carbamazepine) and observation group(50 cases, levetiracetam on the bass of the reference group). The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was 96.00%, which was higher than 80.00% in the reference group(P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the reference group(P<0.05).After treatment, the number of seizures in the observation group was less than that in the reference group,and the duration of seizures was shorter than that in the reference group(P<0.05). After treatment, the levels of S-100β protein(S-100β) and neuron-specific enolase(NSE) in the observation group were lower than those in the reference group(P<0.05). After treatment, the levels of interleukin-1β(IL-1β), interleukin-2(IL-2) and tumor necrosis factor-α(TNF-α) in the observation group were lower than those in the reference group(P<0.05). After treatment, the EEG α band and β band power of the observation group were higher than those of the reference group, while the δ band power was lower than that of the reference group(P<0.05). Conclusion Levetiracetam combinded with carbamazepine is effective in the treatment of patients with epilepsy after hypertensive cerebral hemorrhage, it can not only reduce the number of seizures, but also improve nerve cell factors and inflammatory factors, with high safety, which is worthy of promotion.更多还原