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创面修复力医学

Wound Repairing Mechanomedicine

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【作者】 兰智星王宇晨高之浩都慧聪林昱遥舒茂国李靖卢天健徐峰刘灏

【Author】 LAN Zhixing;WANG Yuchen;GAO Zhihao;DU Huicong;LIN Yuyao;SHU Maoguo;LI Jing;LU Tianjian;XU Feng;LIU Hao;The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi’an Jiaotong University;Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University;Department of Aesthetic, Plastic and Maxillofacial Surgery, First Affiliated Hospital of Xi’an Jiaotong University;Department of Burns and Plastic Surgery, Second Affiliated Hospital of Air Force Military Medical University;State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics;

【通讯作者】 徐峰;刘灏;

【机构】 西安交通大学生物医学信息工程教育部重点实验室西安交通大学仿生工程与生物力学研究所西安交通大学第一附属医院整形美容颌面外科空军军医大学附属唐都医院烧伤科南京航空航天大学航空航天结构力学及控制全国重点实验室

【摘要】 力在临床创面修复中的应用由来已久,但其内在原理仍未系统阐明。近年来,随着生物力学和力学生物学的不断发展,力学因素对创面产生、变化、愈合等一系列过程的内在影响机制逐渐得到揭示。在已有理论、技术研究与临床实践的基础上,提出“创面修复力医学”的概念,从创面生物力学、创面力学生物学、创面力治疗学3个方面系统梳理了相关研究报道,展望了其在未来的可能发展方向,以期为创面护理和瘢痕防治提供新思路。

【Abstract】 The application of mechanics in clinical wound healing has a long history; however, the systematic underlying mechanisms remain unclear. With recent advancements in biomechanics and mechanobiology, the principles regarding how mechanical factors influence the formation, progression, and healing of wounds have gradually been elucidated. Herein, based on progress in theories, technologies, and clinical practices concerning the interplay between mechanics and wound healing, this study introduces the concept of wound-repairing mechanomedicine. Relevant research is systematically reviewed from the perspectives of biomechanics, mechanobiology, and mechanotherapy. Additionally, potential future development directions are prospectively analyzed to provide novel insights into wound care and strategies for preventing scar formation.

【基金】 国家自然科学基金项目(12225208,12302424,12432015);陕西省重点研发计划项目(2022ZDLSF04-03,2023-YBSF-172);陕西省创新能力支撑计划项目(2022TD-48);陕西省高校科协青年人才托举计划项目(20220302)
  • 【文献出处】 医用生物力学 ,Journal of Medical Biomechanics , 编辑部邮箱 ,2025年03期
  • 【分类号】R318.01;R641
  • 【下载频次】35
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