【摘要】 目的 运用网络药理学和分子对接技术探析辛夷清肺饮治疗过敏性鼻炎（AR）的潜在机制。方法 运用TCMSP数据库和HERB数据库检索辛夷清肺饮所含10味药，预测复方活性成分和作用靶点，同时在GeneCards数据库检索“Allergic Rhinitis”得疾病靶点，对复方和疾病靶点取交集；在Cytoscape软件中构建网络进行可视化，筛选出关键活性成分；通过STRING数据库和CytoNCA插件进行网络拓扑学分析，筛选核心靶点；在DAVID数据库中得到交集靶点的富集分析数据，在微生信中进行可视化；最终对筛选出的活性成分和核心靶点进行分子对接。结果 筛选去重后药物与疾病的交集基因共有320个，筛选出主要活性成分10个、核心靶点11个；得到GO和KEGG富集分析数据；分子对接显示_β-谷甾醇、谷甾醇的活性成分与AKTI1靶点结合效果最为显著。结论 辛夷清肺饮中的山奈酚、槲皮素、豆甾醇、异鼠李素、升麻酸、β-谷甾醇、3-表齐墩果酸、谷甾醇（3-表-β-谷甾醇）、亚油酸乙酯等主要活性成分可能通过SRC、STAT3、TP53、AKT1、PIK3R1、HSP90AA1、PIK3CD、EGFR、PTPN11、ESR1、CTNNB1靶点治疗AR。更多还原

【Abstract】 Objective To explore the potential mechanisms of Xinyi Qingfei Yin in the treatment of Allergic Rhinitisusing network pharmacology and molecular docking techniques.Methods The TCMSP database was primarily used to retrieve the 10 herbs contained in Xinyi Qingfei Yin,predicting the active components and their targets in the formula.Simultaneously,the Gene Cards database was searched for “Allergic Rhinitis” to identify overlapping targets between the formula and the disease.A network was constructed and visualized using Cytoscape software(version 3.8.0)to screen for key active components.Network topology analysis was performed using the STRING database and the CytoNCA plugin to identify core targets.The enrichment analysis data of the intersection target was obtained in the DAVID database and visualized in SRplot.Finally,molecular docking was conducted between the selected active components and core targets.Results After removing duplicates,320 intersecting genes between the drug and disease were identified.Ten main active components and 11 core targets were screened out.Obtain the data of GO and KEGG enrichment analysis.Molecular docking showed that the active componentsβ-sitosterol and stigmasterol had the most significant binding affinity with the AKT1 target.Conclusion The main active components in Xinyi Qingfei Yin,including kaempferol,quercetin,stigmasterol,isorhamnetin,cimicifugic acid,β-sitosterol,(4 aS,6 aR,6 aS,6 bR,8 aR,10 R,12 aR,14 bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid,stigmasterol(3-epi-β-sitosterol),and Mandenoll,may treat allergic rhinitis by acting on targets such as SRC,STAT3,TP53,AKT1,PIK3 R1,HSP90 AA1,PIK3 CD,EGFR,PTPN11,ESR1,and CTNNB1.更多还原