【摘要】 目的：探讨阿奇霉素涂布种植体对慢性牙周炎致牙列缺损患者炎症反应及种植体骨结合能力的影响。方法：选取2023年6月—2024年12月如皋市人民医院收治的100例慢性牙周炎致牙列缺损患者，将其随机分为研究组（给予阿奇霉素涂布钛合金种植体治疗，n=50）和对照组（给予钛合金种植体治疗，n=50）。比较两组炎症因子水平、骨结合能力。结果：治疗前，两组患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平对比，差异不显著（P > 0.05）；治疗后，研究组患者血清碱性磷酸酶（ALP）水平、种植体—骨结合率均更高（P<0.05）,TNF-α、IL-6、IL-1β水平均更低（P<0.05）。结论：应用阿奇霉素涂布种植体能够有效减轻慢性牙周炎致牙列缺损患者炎症反应，增强种植体骨结合能力。更多还原

【Abstract】 Objective: To investigate the effect of azithromycin-coated implants on inflammatory response and osseointegration ability in patients with dentition defects caused by chronic periodontitis. Methods: A total of 100 patients with dentition defects caused by chronic periodontitis admitted to Rugao People’s Hospital from June 2023 to December 2024 were selected and randomly divided into a study group(treated with azithromycin-coated titanium alloy implants, n=50) and a control group(treated with titanium alloy implants, n=50). The levels of inflammatory factors and osseointegration ability were compared between the two groups. Results: Before treatment, there were no significant differences in serum levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), and interleukin-1β(IL-1β) between the two groups(P > 0.05). After treatment, the study group exhibited higher serum alkaline phosphatase(ALP) levels and implant-bone integration rates, along with lower TNF-α, IL-6, and IL-1β levels(P < 0.05). Conclusion: Azithromycin-coated implants can effectively reduce inflammatory response and enhance osseointegration ability in patients with dentition defects caused by chronic periodontitis.更多还原