【摘要】 目的 比较多焦点硬性透气性角膜接触镜（MFRGP）与单焦点硬性透气性角膜接触镜（SVRGP）控制8～14岁高度近视青少年近视进展的有效性及安全性。方法 纳入2021至2023年于广东省人民医院就诊的高度近视青少年患者120例。根据近视矫正方式分为MFRGP组（58例）和SVRGP组（62例）。随访1年，评估患者等效球镜度（SE）、眼轴长度（AL）年增长量、戴镜视力、残余SE，以及角膜不良反应发生率。结果 2组高度近视患者SE和AL均呈现增长趋势。MFRGP组SE增长量（-0.40±0.31）D,AL增长量（0.25±0.13）mm,SVRGP组SE增长量（-0.62±0.37）D,AL增长量（0.38±0.27）mm,2组患者SE及AL的增长量变化组间及组内比较差异均具有统计学意义（均P<0.05）。12个月时MFRGP组戴镜视力好于SVRGP组[LogMAR:+0.02±0.06 vs.+0.10±0.09,P<0.001]，残余SE轻于SVRGP组[（-0.29±0.31）D vs.(-0.78±0.71)D,P=0.002]。2组均未发生严重并发症，MFRGP组发生不良反应的概率略高于SVRGP组，但差异无统计学意义，经干预可缓解。结论 MFRGP在控制青少年高度近视进展方面优于SVRGP，且安全性可控，MFRGP对近视防控具有较好的临床疗效。更多还原

【Abstract】 Objective To compare the efficacy and safety of multifocal rigid gas permeable(MFRGP) lenses versus single-vision rigid gas permeable(SVRGP) lenses in controlling myopia progression in adolescents aged 8 to 14 with high myopia. Methods A total of 120 adolescent patients with high myopia, who visited the Guangdong Provincial People’s Hospital between 2021 and 2023, were enrolled. Based on their myopia correction method, the patients were divided into the MFRGP group(58 cases) and the SVRGP group(62 cases). Follow-up was conducted for 1 year, during which we assessed their spherical equivalent(SE), annual increase of axial length(AL), visual acuity with lenses, residual SE, and the incidence of corneal adverse reactions. Results Both groups showed an increasing trend in SE and AL. In the MFRGP group, the SE change was(-0.40±0.31) D and and the AL growth was(0.25±0.13) mm, while in the SVRGP group, the SE change was(-0.62±0.37) D and the AL growth was(0.38±0.27) mm. The differences in the SE and AL increment changes between and within the two groups were statistically significant(all P < 0.05). At 12 months, the MFRGP group had better corrected visual acuity than the SVRGP group [LogMAR: +0.02±0.06 vs. +0.10±0.09, P < 0.001], and the residual SE was significantly lower than that in the SVRGP group [(-0.29±0.31)D vs.(-0.78±0.71)D,P = 0.002]. No severe complications occurred in either group, and although the MFRGP group had a slightly higher probability of adverse reactions compared with the SVRGP group, the difference was not statistically significant and could be alleviated with intervention. Conclusions MFRGP is superior to SVRGP in controlling the progression of high myopia in adolescents, and its safety is controllable. MFRGP shows better clinical efficacy in myopia prevention and control.更多还原