【摘要】 该文综述了压力性损伤的发生机制，重点探讨了其形成因素、创面愈合机制及相关信号通路。深入分析了压力性损伤发病机制中的关键生化途径，以及这些途径如何通过信号传导影响伤口愈合过程，导致伤口愈合受损。首次系统性地描述了信号通路在调控压力性损伤发病机制中的作用，并阐明了程序性死亡在压力性损伤病理生理过程中的意义。旨在为实验研究、临床预防、治疗及精准护理干预提供理论依据和指导。更多还原

【Abstract】 This paper summarizes the mechanism of pressure injuries, focusing on the factors contributing to their formation, the mechanisms of wound healing and the associated signaling pathways.In-depth analysis of the key biochemical pathways involved in the pathogenesis of pressure injuries and how these pathways influence the wound healing process through signaling, ultimately leading to impaired healing.The role of signal pathways in regulating the pathogenesis of pressure injuries is systematically described for the first time, and the significance of programmed cell death in the pathophysiological process is expounded.The study aims to provide theoretical foundation and guidance for experimental research, clinical prevention, treatment and precision nursing interventions.更多还原