【摘要】 目的 探讨甘油三酯葡萄糖乘积（TyG）指数、血浆动脉硬化指数（AIP）、系统性免疫炎症（SII）与冠状动脉慢性完全闭塞性病变（CTO）的相关性。方法 回顾性分析2021年11月至2023年12月因疑诊冠心病在邯郸市第一医院住院行冠状动脉血管造影术（CAG）的患者，根据CAG结果，将符合标准的患者分为CTO组（202例）和非CTO组（340例），收集患者血液中包括中性粒细胞计数（NE）、血小板计数（Plt）、空腹血糖（FBG）、血肌酐（Scr）、血清肌钙蛋白I(cTnI)、总胆固醇（CHOL）、丙氨酸氨基转移酶（ALT）、低密度脂蛋白胆固醇（LDL-C）等实验室指标，并计算TyG、AIP、SII指数。Logistic回归分析方法分析CTO患者的危险因素，绘制ROC曲线分析各指的标预测价值。结果 CTO组患者的TyG指数、AIP指数、SII指数水平明显高于非CTO组TyG指数[（9.05±0.68）比（8.53±0.40）、（0.61±0.10）比（0.51±0.08）、（2168.04±1417.72）比（987.47±770.79）]，结果具有显著差异（P<0.05），二元Logistic回归分析发现，TyG、AIP、SII指数是CTO的危险因素。ROC曲线显示，TyG、AIP、SII指数在ROC曲线测得曲线下面积分别为0.726(95%CI 0.679～0.773,P<0.001),0.787(95%CI 0.745～0.829,P<0.001)0.728(95%CI 0.679～0.776,P<0.001)。结论 TyG、AIP、SII指数与CTO密切相关，可以作为诊断预测CTO的简便的实验室指标。更多还原

【Abstract】 Objective To investigate the correlation between triglyceride glucose product(TyG) index,plasma arteriosclerosis index(AIP), systemic immune inflammation(SII) and chronic total occlusion of coronary artery disease(CTO). Methods A retrospective analysis was made in the patients who underwent coronary angiography(CAG) in the First Hospital of Handan City from November 2021 to December 2023 due to suspected coronary heart disease. According to CAG results, the patients who met the criteria were divided into CTO group(202 cases) and non-CTO group(340 cases). The blood samples including neutrophil count(NE), platelet count(Plt), fasting blood glucose(FBG), serum creatinine(Scr), Serum troponin I(cTnI), total cholesterol(CHOL),alanine aminotransferase(ALT), low density lipoprotein cholesterol(LDL-C) and other laboratory indicators were recorded, and TyG, AIP and SII index were calculated. Logistic regression analysis was used to analyze the risk factors to the CTO patients, ROC curve was drawn to analyze the predictive value of each index. Results TyG index, AIP index and SII index of the patients with CTO were significantly higher than that of non-CTO group[(9.05 ± 0.68) vs.(8.53 ± 0.40)、(0.61 ± 0.10) vs.(0.51 ± 0.08)、(2168.04 ± 1417.72) vs.(987.47 ± 770.79)], with significant differences. Binary Logistic regression analysis show that TyG, AIP and SII index were the risk factors of CTO(P<0.05). ROC curve analysis showed that the areas under the curve(AUC) of the TyG index, AIP, and SII index were 0.726(95%CI: 0.679-0.773, P<0.001), 0.787(95%CI: 0.745-0.829, P<0.001), and 0.728(95%CI:0.679-0.776, P<0.001), respectively. Conclusion TyG, AIP and SII indices are closely correlated with CTO and can be used as simple laboratory indexes for diagnosis and prediction of CTO.更多还原