【摘要】 卵圆孔未闭(PFO)是一种常见的结构异常性先天性心脏病，普通人群中约25%的人存在PFO。既往认为PFO是一种良性改变而对其缺乏关注，现大量研究已证实PFO与隐源性脑卒中、偏头痛、减压病、晕厥等存在关联，最新报告显示也可能与癫痫、心绞痛等有关，其相关疾病谱在不断增加。针对PFO相关疾病的治疗，研究显示封堵术效果较好且可降低某些疾病的复发风险，但其安全性与有效性尚不完全清楚。现对PFO相关疾病及封堵术效果的最新研究进展做一综述。更多还原

【Abstract】 Patent foramen ovale(PFO) is a common congenital heart disease with structural abnormalities, and about twenty-five percent of the general population have PFO.In the past, PFO was considered a benign change and lacked attention.Presently, a large number of studies have confirmed that PFO is associated with cryptogenic stroke, migraine, decompression sickness, syncope, etc.The latest reports show that it may also be related to epilepsy, angina pectoris, etc, and its spectrum of related diseases is increasing.Regarding the treatment of diseases related to PFO,studies have shown that closure has good therapeutic effects and can reduce the recurrence rate of certain diseases, but its safety and effectiveness are not yet fully understood.This article summarizes the latest literature reports on diseases related to PFO and closure effects.更多还原