【摘要】 目的 分析并探讨环泊酚与苯磺酸瑞马唑仑对老年腹腔镜胆囊切除术患者全身麻醉的麻醉效果。方法便利选取2024年1月—2025年1月齐齐哈尔医学院附属第二医院收治的100例老年腹腔镜胆囊切除术患者为研究对象，按麻醉方法不同分为两组，每组50例。两组患者均给予全身静脉麻醉，对照组增加环泊酚输注，观察组增加苯磺酸瑞马唑仑输注。比较两组围术期血流动力学指标、麻醉相关指标、术后谵妄发生情况、白介素细胞6(interleukin 6, IL-6)水平及不良反应发生情况。结果 在术中不同时间点，观察组患者的平均动脉压、心率和血氧饱和度较对照组更平稳，差异均有统计学意义（P均<0.05）。观察组麻醉诱导时间、苏醒时间及离室时间短于对照组，差异均有统计学意义（P均<0.05）。观察组术后1 d的谵妄发生率为4.00%(2/50)，低于对照组的16.00%(8/50)，差异有统计学意义（χ~2=4.000,P<0.05）。观察组术后1 d的IL-6水平为（96.61±10.25）ng/mL，低于对照组为（105.11±12.44）ng/mL，差异有统计学意义（t=3.765,P<0.05）。两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。结论 与环泊酚相比，苯磺酸瑞马唑仑对老年患者全身麻醉术有更好的干预效果，能够缩短麻醉起效时间，有助于患者的苏醒，稳定患者检查过程中的血流动力学，降低患者术后谵妄发生率和IL-6水平，且安全性良好。更多还原

【Abstract】 Objective To analyze and discuss the anesthetic effect of cyclopophenol and remazolam benzenesulfonate on general anesthesia in elderly patients undergoing laparoscopic cholecystectomy. Methods A total of 100 elderly patients undergoing laparoscopic cholecystectomy admitted to The Second Affiliated Hospital of Qiqihar Medical College from January 2024 to January 2025 were conveniently selected as the research objects. They were divided into two groups according to different anesthesia methods, with 50 cases in each group. The patients in the two groups were given general intravenous anesthesia. The control group increased the infusion of cyclopophenol, and the observation group increased the infusion of remazolam benzenesulfonate. Perioperative hemodynamic indexes, anesthesia-related indexes, postoperative delirium, interleukin 6(IL-6) level and adverse reactions were compared between the two groups. Results At different time points during the operation, the mean arterial pressure, heart rate and blood oxygen saturation of the observation group were more stable than those of the control group, and the differences were statistically significant(all P<0.05). The anesthesia induction time, recovery time and departure time in the observation group were shorter than those in the control group, and the differences were statistically significant(all P<0.05). The incidence of delirium at 1 d after operation in the observation group was 4.00%(2/50), which was lower than 16.00%(8/50) in the control group, and the difference was statistically significant(χ~2=4.000, P<0.05). The level of IL-6 in the observation group was(96.61±10.25) ng/mL, which was lower than(105.11±12.44) ng/mL in the control group, and the difference was statistically significant(t=3.765, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Compared with cyclophnol, remazolam benzenesulfonate has a better intervention effect on general anesthesia in elderly patients. It can shorten the onset time of anesthesia, help patients wake up, stabilize hemodynamics during examination, reduce the incidence of postoperative delirium and IL-6 level, and has good safety.更多还原