【摘要】 目的探讨育龄期女性缺铁性贫血（iron deficiency anemia, IDA）患者血清富亮氨酸α2-糖蛋白1(leucine-rich α-2 glycoprotein 1, LRG1)、平均红细胞体积（mean corpuscular volume, MCV）、红细胞分布宽度（red blood cell distribution width, RDW）及铁代谢相关指标的表达水平及临床意义。方法 目的选取2022年3月—2024年3月在常州市武进人民医院住院的79例育龄女性IDA患者为研究对象，作为IDA组，再根据贫血严重程度分为轻度IDA组（43例）和中重度IDA组（36例）。同期选取76名健康女性作为对照组。比较3组LRG1、MCV、RDW及铁代谢指标[血清铁、可溶性转铁蛋白受体（soluble transferrin receptor, sTfR）、铁蛋白（ferritin, FER）]的差异，并分析LRG1、MCV、RDW及铁代谢指标与血红蛋白（hemoglobin, Hb）水平的相关性。结果对照组与IDA组LRG1、MCV、RDW及铁代谢指标比较，差异均有统计学意义（P均<0.05）。中重度IDA组MCV、血清铁水平低于轻度IDA组，RDW、sTfR、LRG1水平高于轻度IDA组，差异均有统计学意义（P均<0.05）。MCV、血清铁变化程度与Hb水平成正相关（r=0.585,0.398;P均<0.001）。LRG1、sTfR与Hb水平成负相关（r=-0.416,-0.510;P均<0.001）。结论 育龄期女性IDA患者LRG1、MCV、RDW及铁代谢指标明显异常，这些指标的变化与贫血的严重程度密切相关，LRG1和sTfR与Hb呈负相关关系，而MCV和血清铁与Hb则呈正相关关系。更多还原

【Abstract】 Objective To explore the expression levels and clinical significance of serum leucine-rich α-2 glycoprotein 1(LRG1), mean corpuscular volume(MCV), red blood cell distribution width(RDW), and iron metabolismrelated indicators in reproductive-age women with iron deficiency anemia(IDA). Methods A total of seventy-nine reproductive-age women with IDA admitted to Changzhou Wujin People’s Hospital from March 2022 to March 2024 were purposefully selected as the research objects(IDA group), and they were further divided into mild IDA subgroup(forty-three cases) and moderate-to-severe IDA subgroup(thirty-six cases) according to the severity of anemia. During the same period, seventy-six healthy women were selected as the control group. The differences in LRG1, MCV, RDW, and iron metabolism indicators [serum iron, soluble transferrin receptor(sTfR), ferritin(FER)] among the three groups were compared, and the correlation between LRG1, MCV, RDW, iron metabolism index and hemoglobin(Hb) level was analyzed. Results There were statistically significant differences in LRG1, MCV, RDW, and iron metabolism indicators between the control group and the IDA group(all P<0.05). The levels of MCV and serum iron in the moderate-to-severe IDA subgroup were lower than those in the mild IDA subgroup, while the levels of RDW, sTfR, and LRG1 were higher than those in the mild IDA subgroup, differences were statistically significant(all P<0.05). The changes in MCV and serum iron were positively correlated with Hb levels(r=0.585, 0.398; all P<0.001). LRG1 and sTfR were negatively correlated with Hb levels(r=-0.416,-0.510; all P<0.001). Conclusion LRG1, MCV, RDW and iron metabolism indexes were significantly abnormal in reproductive-age women with IDA patients. The changes of these indexes were closely related to the severity of anemia. LRG1 and sTfR were negatively correlated with Hb, while MCV and serum iron were positively correlated with Hb.更多还原