【摘要】 目的 研究新辅助化疗治疗晚期卵巢癌效果。方法 随机选取山西省肿瘤医院于2020年1月—2022年11月收治的100例晚期卵巢癌患者为研究对象。按照治疗方式不同分为观察组和对照组，其中观察组接受新辅助化疗后手术（n=50），对照组接受常规手术后化疗（n=50），分析两组治疗效果。结果 观察组治疗总有效率高于对照组，不良反应总发生率低于对照组，差异均有统计学意义（P均<0.05）。治疗后，观察组脱水量为（762.02±35.43)m L、出血量为（419.12±33.31)m L、肿瘤面积为（7.58±1.09)cm~2，优于对照组的（125.13±14.66)m L、（902.56±35.81)m L、（14.75±0.98)cm~2，差异均有统计学意义（t=117.452,69.896,34.588;P均<0.05）。观察组血清肿瘤标志物水平、血清血管内皮生长因子和基质金属蛋白酶2水平以及T细胞亚群水平均优于对照组，差异均有统计学意义（P均<0.05）。结论 新辅助化疗与手术联合应用于晚期卵巢癌治疗时，可提升治疗有效率，同时能显著降低血清肿瘤标志物水平，在改善患者免疫功能方面亦有积极作用，且不良反应发生率更低。该治疗方案在提升疗效的同时兼具安全性，可作为晚期卵巢癌的优选治疗策略。更多还原

【Abstract】 Objective To study the effect of neoadjuvant chemotherapy in the treatment of advanced ovarian cancer.Methods A total of 100 patients with advanced ovarian cancer admitted to Shanxi Cancer Hospital from January 2020to November 2022 were randomly selected as the study subjects.According to different treatment methods,they were divided into observation group and control group.The observation group received neoadjuvant chemotherapy before surgery (n=50),and the control group received conventional surgery followed by chemotherapy (n=50).The therapeutic effects of the two groups were analyzed.Results The total effective rate of treatment in the observation group was higher than that in the control group,the total incidence of adverse reactions was lower than that in the control group,and the differences were statistically significant (both P<0.05).After treatment,the dehydration volume,blood loss,and tumor area in the observation group were (762.02±35.43) m L,(419.12±33.31) m L,and (7.58±1.09) cm2,which were better than (125.13±14.66) m L,(902.56±35.81) m L,(14.75±0.98) cm2 in the control group,the differences were statistically significant (t=117.452,69.896,34.588;all P<0.05).The levels of serum tumor markers,serum vascular endothelial growth factor,matrix metalloproteinase 2 and T cell subsets in the observation group were better than those in the control group,and the differences were statistically significant (all P<0.05).Conclusion When neoadjuvant chemotherapy is combined with surgery for the treatment of advanced ovarian cancer,it can improve the treatment effective rate,significantly reduce serum tumor marker levels,positively improve the immune function of patients,and have a lower incidence of adverse reactions.This treatment regimen not only enhances curative effect but also has safety,and can be used as an optimal treatment strategy for advanced ovarian cancer.更多还原