【摘要】 目的 本研究旨在分析国内外抑郁症与炎症反应领域的发展趋势，识别研究热点和前沿方向。通过梳理相关研究，探讨炎症因子、肠道菌群、氧化应激等在抑郁症中的作用，为揭示病理机制提供新视角。方法 使用CiteSpace软件，分析2011年1月1日～2024年9月1日期间发表于Web of Science核心数据库及中国知网等平台的相关文献，构建研究热点与趋势的可视化图谱。结果 共纳入1 942篇文献。2011～2017年文献增长缓慢，2023年达峰值。中国发文量最多，但国际合作深度不足；美国在国际合作网络中居核心地位。国内机构合作松散，国外合作紧密且呈全球化趋势。关键词共现分析显示，炎症因子、肠道菌群和氧化应激是核心主题。中文文献偏重中医药在炎症调节中的作用，英文文献聚焦分子机制研究，采用系统生物学等方法揭示炎症与抑郁症的复杂关系。结论 国内外研究分别侧重中医药应用与分子机制探索。未来应结合传统医学与现代生物学，为抑郁症精准诊疗提供依据。更多还原

【Abstract】 Objective This study aims to systematically analyze global research trends in the field of depression and inflammatory responses, identifying key research hotspots and emerging directions. By reviewing relevant studies, it explores the roles of inflammatory factors, gut microbiota, and oxidative stress in depression, offering new insights into its underlying pathological mechanisms. Methods Using CiteSpace software, we analyzed literature published from January 1, 2011, to September 1, 2024, in the Web of Science Core Collection and Chinese databases, including CNKI. Visualized bibliometric maps were constructed to explore research trends and hotspots. Results A total of 1 942 articles were included. From 2011 to 2017, publication growth was slow, peaking in 2023. China led in publication volume but showed limited depth in international collaborations, whereas the United States played a central role in the global collaboration network. Domestic institutional collaborations were fragmented and regionally concentrated, while international institutions demonstrated tighter, globalized collaborations. Keyword co-occurrence analysis revealed that inflammatory cytokines, gut microbiota, and oxidative stress are core research themes. Chinese studies primarily explored the role of traditional Chinese medicine in modulating inflammation, whereas international studies emphasized molecular mechanisms using systems biology and network pharmacology to investigate the intricate relationship between inflammation and depression. Conclusion Domestic research highlights traditional Chinese medicine applications, while international studies prioritize molecular mechanisms. Future research should integrate traditional medicine with modern biological approaches to advance precision diagnosis and treatment strategies for depression.更多还原