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AMPK对心脏交感应激损伤的保护作用及机制

Protective effect and mechanism of AMPK on stress damage of cardiac sympathetic nervous system

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【Author】 Chen Jichun;Zhao Mingming;Liu Aiming;Zhang Youyi;Xiao Han;Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Beijing Key Laboratory of Cardiovascular Receptors Research; Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences;

【通讯作者】赵明明;肖晗;

【机构】北京大学第三医院心内科、血管医学研究所；血管稳态与重构全国重点实验室(北京大学)；国家卫生健康委心血管分子生物学与调节肽重点实验室；心血管受体研究北京市重点实验室,中国医学科学院医学科研管理/代谢性心血管疾病基础与临床研究创新单元；

【摘要】 AMP活化的蛋白质激酶(AMPK)是细胞中重要的能量感受器,可调节细胞应激反应。交感肾上腺素受体的过度激活,促进了高血压、冠心病、心力衰竭等心血管疾病的发生和发展。本文综述了AMPK在交感神经过度激活导致心脏损伤中的保护作用和机制及其潜在的临床价值。更多还原

【Abstract】 AMP-activated protein kinase(AMPK) is a critical cellular energy sensor that regulates cell stress responses. Over activation of the sympathetic nervous system and adrenergic receptors significantly impacts cardiovascular function, contributing to the onset and progression of cardiovascular diseases such as hypertension, coronary artery disease, and heart failure. This article provides a comprehensive review of the protective mechanisms of AMPK on cardiac stress damage of sympathetic over activation and its potential clinical implications.更多还原

【关键词】交感神经系统；肾上腺素受体； AMP活化的蛋白质激酶；心脏疾病；
【Key words】 Sympathetic nervous system； Adrenergic receptor； AMP-activated protein kinase； Cardiac disease；

【基金】国家自然科学基金(32371158、82104159);中国医学科学院医学与健康科技创新工程项目(2021-I2M-5-003)~~

【文献出处】中国心血管杂志 ,Chinese Journal of Cardiovascular Medicine , 编辑部邮箱 ,2025年01期

【分类号】R54
【下载频次】96

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