【摘要】 目的 探讨血清微管相关蛋白1轻链3-Ⅱ(LC3-II)联合微炎症指标对维持性血液透析患者预后的预测价值。方法 选取2020年1月—2022年1月我院收治的维持性血液透析患者92例为研究对象，治疗后进行1年的随访，根据随访生存情况结果分为生存组(n=77)和死亡组(n=15)。比较两组一般资料、并使用ELISA法检测LC3-II、微炎症指标[超敏C反应蛋白(hs-CRP)、血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)]水平，ROC曲线分析血清LC3-II联合微炎症指标对维持性血液透析患者预后的预测价值。结果 死亡组患者营养不良发生率、血钾、肌酐、尿素氮水平高于生存组患者，残肾滤过率低于生存组患者(P<0.05)。与生存组比较，死亡组LC3-II水平较低，hs-CRP、SAA、IL-6水平较高(P<0.05)。多因素Logistics回归分析显示，营养不良、残肾滤过率、血钾、肌酐、尿素氮、LC3-II、hs-CRP、SAA、IL-6为影响患者预后的危险因素(P<0.05)。ROC曲线显示，与LC3-II、hs-CRP、SAA、IL-6单项检测相比，4者联合检测对维持性血液透析患者预后具有较高的预测价值(P<0.05)。结论 维持性血液透析患者预后与多种因素相关，且死亡患者体内LC3-II表达水平较低，hs-CRP、SAA、NLR、IL-6表达水平较高，联合检测LC3-II、hs-CRP、SAA、IL-6表达，可用于维持性血液透析患者预后的预测。更多还原

【Abstract】 Objective To analyze the predictive value of serum microtubule-associated protein 1 light chain 3-II(LC3-II) combined with microinflammation index on the prognosis of maintenance hemodialysis patients. Methods 92 patients who underwent maintenance hemodialysis treatment in our hospital from January 2020 to January 2022 were selected as the research subjects of this study. After treatment, they were followed up for 1 year. According to the follow-up results, they were divided into a survival group of 77 cases and a death group of 15 cases. Observed the general information of each group and used ELISA to detect LC3-II Hs CRP, SAA, IL-6 levels. ROC curve was used to analyzed the predictive value of serum LC3-II combined with micro inflammatory markers for the prognosis of maintenance hemodialysis patients. Results The incidence of malnutrition, serum potassium, creatinine and urea nitrogen levels in the deceased patients were higher than those in the surviving patients, and the filtration rate of residual kidney was lower than that in the surviving patients(P<0.05). Compared with the survival group, the levels of LC3-II in the death group were lower, and the levels of hs-CRP, SAA and IL-6 were higher(P<0.05). Multi-factor logistic regression analysis showed that malnutrition, residual kidney filtration rate, blood potassium, creatinine, urea nitrogen, LC3-II, hs-CRP, SAA and IL-6 were the risk factors affecting the prognosis of patients(P<0.05). ROC curve displayed, the combined detection of LC3-II, hs-CRP, SAA, and IL-6 had a higher predictive value for the prognosis of maintenance hemodialysis patients(P<0.05). Conclusion The prognosis of maintenance hemodialysis patients is related to many factors, and the expression level of LC3-II in dead patients is low, while the expression levels of hs-CRP, SAA and IL-6 are high. Detection of LC3-II, hs-CRP, SAA and IL-6 can be used to predict the prognosis of maintenance hemodialysis patients.更多还原