【摘要】 目的 探讨泡沫硬化剂与腔内激光治疗大隐静脉曲张小腿段主干的临床疗效与安全性。方法 收集2021年10月至2023年9月于深圳市第二人民医院（深圳大学第一附属医院）就诊的130例下肢静脉曲张患者，按照大隐静脉曲张小腿段主干手术方式的不同将其分为硬化剂组（n=87）和激光组（n=67），比较两组患者手术时间、术中出血量、术后24 h视觉模拟疼痛评分（VAS）、术后静脉临床严重程度评分（VCSS）及术后并发症发生率。结果 观察组的两组患者均手术成功，硬化剂组患者术后24 h VAS评分低于激光组患者，差异有统计学意义（P﹤0.05）。两组患者患肢手术时间、术中出血量、VCSS评分比较，差异均无统计学意义（P﹥0.05）。硬化剂组患者患肢术后并发症发生率为13.8%(12/87)，低于激光组患者的26.9%(18/67)，差异有统计学意义（P﹤0.05）。硬化剂组患者患肢皮肤感觉异常发生率为3.4%(3/87)，低于激光组患者的11.9%(8/67)，但差异无统计学意义（P﹥0.05）。观察组患者术后并发症发生率低于对照组，均无严重并发症发生。差异有统计学意义（P﹤0.05）。结论 泡沫硬化剂治疗大隐静脉曲张小腿段主干的临床疗效与腔内激光热消融相似，但安全性较高，值得在临床上推广应用。更多还原

【Abstract】 Objective To explore the clinical efficacy and safety of foam sclerosing agent and intracavitary laser in the treatment of lower leg trunk of great saphenous varicose vein. Method A total of 130 patients with varicose veins of the lower extremity who were treated at the Shenzhen Second People’s Hospital(the First Affiliated Hospital of Shenzhen University) from October 2021 to September 2023 were collected. They were divided into the sclerotherapy group(n=87) and the laser group(n=67) based on the different surgical methods for the lower leg trunk of great saphenous varicose vein. The operation time, intraoperative blood loss, 24-hour postoperative visual analogue scale(VAS) pain score, postoperative venous clinical severity score(VCSS), and postoperative complication rate were compared between the two groups. Result Both groups of patients underwent successful surgery. The VAS score of the patients in the sclerotherapy group was lower than that of the laser group 24 hours after the operation, the difference was statistically significant(P<0.05). There were no statistically significant differences in the operation time of the affected extremity, intraoperative blood loss, and VCSS score between the two groups(P>0.05). The incidence of postoperative complications in the affected limbs of the sclerotherapy group was 13.8%(12/87), lower than 26.9%(18/67) in the laser group, the difference was statistically significant(P<0.05). The incidence of skin sensory abnormalities in the affected limbs of the sclerotherapy group was 3.4%(3/87), lower than 11.9%(8/67) in the laser group, but the difference was not statistically significant(P>0.05). Conclusion The clinical efficacy of foam sclerosing agent in treating the lower leg trunk of great saphenous varicose vein is similar to that of endovascular laser thermal ablation, but it is safer and worthy of clinical promotion and application.更多还原