【摘要】 目的 运用限制性立方样条模型，分析颈围与高血压之间的剂量-反应关系及其关联强度。方法 数据来源于2023年的自贡市“呼吸健康筛查”数据，采用分层随机抽样方式，选取了35～75岁的自贡市居民进行问卷调查、身体测量及健康检查。研究应用了logistic回归模型和限制性立方样条模型，以探讨颈围与高血压之间的关联。结果 最终纳入了4 142名年龄在35～75岁之间的研究对象，高血压的患病率为36.5%。调整混杂因素后，低颈围组与高血压患病关联的的OR值为1.20(95%CI:1.01～1.43),高颈围组与高血压患病关联的OR值为1.42(95%CI:1.17～1.72)。限制性立方样条分析结果显示，在总体人群及非中性型肥胖人群中，颈围与高血压患病之间呈现出U型的非线性剂量-反应关系(总体趋势P<0.001,非线性P<0.05)。而在中性型肥胖人群中，高血压患病与颈围之间则表现为线性的剂量-反应关系(总体趋势P<0.001,P非线性>0.05)。结论 颈围与高血压患病密切相关且二者存在U型剂量-反应关系。更多还原

【Abstract】 Objective To investigate the dose-response relationship between neck circumference and hypertension using restricted cubic spline modeling.Methods The data for this study were sourced from the 2023 Zigong Respiratory Health Screening Program. A stratified random sample of Zigong residents aged 35 to 75 years was selected to participate in questionnaire surveys, physical measurements, and health examinations. Logistic regression and restricted cubic spline models were employed to investigate the relationship between neck circumference and hypertension.Results A total of 4 142 participants aged 35-75 years were enrolled, with a hypertension prevalenceof 36.5%. After adjusting for confounders, the odds ratios(OR) associated with hypertension prevalencewas 1.20(95%CI: 1.01-1.43) for the low neck circumference group and 1.42(95%CI: 1.17-1.72) for the high neck circumference group. Restricted cubic spline analysis showed a U-shaped nonlinear dose-response relationship between neck circumference and prevalence of hypertension in the overall population and in the noncentrally obese population(P< 0.001 for overall trend and P<0.05 for nonlinearity). In contrast, in the centrally obese population, a linear dose-response relationship was demonstrated between prevalence of hypertension and neck circumference(overall trend P<0.001, nonlinear P>0.05).Conclusion Neck circumference is strongly associated with hypertension and there is a U-shaped dose-response relationship.更多还原