【摘要】 目的 探讨DDX39在胃癌、胃低级别上皮内瘤变、慢性非萎缩性胃炎等不同组织中的表达情况及其临床意义。方法 纳入2019年1月至2022年1月就诊于贵阳市第二人民医院消化内科门诊及病房经胃镜检查及活检、组织病理检查证实的慢性非萎缩性胃炎(200例)、胃低级别上皮内瘤变(200例)、胃癌(150例)病例，收集相关临床资料及胃黏膜组织，采用免疫组化法检测组织中DDX39表达情况。对胃低级别上皮内瘤变患者胃镜下大体改变、组织病理学变化及活检组织中DDX39表达情况进行随访。结果 DDX39在胃癌、胃低级别上皮内瘤变中表达较慢性非萎缩性胃炎组显著增加，且DDX39在胃癌组织中表达高于胃低级别上皮内瘤变组织。随访200例胃低级别上皮内瘤患者胃镜下表现、组织中DDX39表达情况，平均随访时长为24月，发现7例发生病理升级，其中6例转化为胃高级别上皮内瘤变，1例转化为胃癌，发生病理升级的病例胃黏膜组织中DDX39的表达量高于未发生病理升级者。结论 DDX39在胃低级别上皮内瘤变组织中高表达。DDX39的表达量与其病理升级相关，DDX39可作为胃低级别上皮内瘤变预测其病理升级的指标，同时有望作为评估是否需要行内镜下治疗的一个重要标志物。更多还原

【Abstract】 Objective To investigate the expression of DDX39 in gastric cancer, gastric low-grade intraepithelial neoplasia and chronic non-atrophic gastritis and its clinical significance. Methods From January 2019 to January 2022, the patients were admitted to the outpatient department and ward of Digestive System Department of Guiyang Second People′s Hospital. The tissue pathology examination confirmed cases of chronic non-atrophic gastritis(200 cases), gastric low-grade intraepithelial neoplasia(200 cases) and gastric cancer(150 cases), collected relevant clinical information and sponge tissue, and used immunohistochemistry to detect DDX39 expression in tissue. The gross changes, pathological changes and the expression of DDX39 in biopsy were followed up. Results The expression of DDX39 in gastric cancer and gastric low-grade intraepithelial neoplasia was significantly increased in the group of chronic non-atrophic gastritis, and the expression of DDX39 in gastic cancer tissue was higher than in gastric low-grade intraepithelian neoplasia tissue. The appearance under endoscopy and expression of DDX39 in 200 patients with gastric low-grade intraepithelial neoplasia were followed up for 24 months on average. Seven patients were found to have a pathological escalation, six of whom turned into gastic high-grade intraepithelial neoplasia and one into gastic cancer. The expression of DDX39 in gastric mucosa was higher in those who had a pathogenic escalation than in those without a pathologic escalation. Conclusion DDX39 is highly expressed in gastric low-grade intraepithelial neoplasia. The expression of DDX39 is associated with its pathological escalation, and DDX39 could be used as an indicator for predicting the pathological escalations of gastic low-grade intraepithelial neoplasia, and is expected to be an important marker for assessing whether subcutaneous therapy is needed.更多还原