【摘要】 目的 探讨蒲地蓝消炎口服液控释药条治疗慢性牙周炎的临床效果。方法 选取2023年12月～2025年3月间在河北医科大学口腔医院治疗的402例慢性牙周炎患者，采用随机数字对照表法分为中药组、西药组和对照组，每组134例。对照组仅采用牙周基础治疗，中药组牙周基础治疗后于牙周袋内置蒲地蓝消炎口服液控释药条，西药组牙周基础治疗后于牙周袋内置盐酸米诺环素软膏。三组疗程均为4周。观察比较三组牙周炎相关指数、局部体征、炎症因子、氧化应激指标、临床疗效和药物不良反应情况。结果 治疗后，三组牙周炎相关指数、局部体征、炎症因子等各项评分均低于治疗前（P<0.05）；且治疗后中药组和西药组评分明显低于对照组（P<0.05），而中药组各指标评分最低（P<0.05）。治疗后各组氧化应激指标较治疗前有明显变化，差异有统计学意义（P<0.05），且中药组变化最明显（P<0.05）。治疗后中药组临床疗效（96.27%）明显高于西药组（81.34%）和对照组（65.67%），差异有统计学意义（P<0.05）。在不良反应方面，中药组的发生率（0.75%）明显低于西药组（11.19%）(P<0.05)。结论 蒲地蓝消炎口服液控释药条治疗慢性牙周炎具有良好的疗效，且副作用小，值得在口腔临床推广应用。更多还原

【Abstract】 Objective To explore the clinical effect of Pudilan anti-inflammatory oral liquid controlled-release drug strip in the treatment of chronic periodontitis.Methods 402 patients with chronic periodontitis treated at the Stomatological Hospital of Hebei Medical University from December 2023 to March 2025 were selected and randomly divided into a traditional Chinese medicine group, a western medicine group, and a control group using a random number controlled table method, with 134 patients in each group. The control group only received periodontal basic treatment, while the traditional Chinese medicine group had a controlled release strip of Pudilan anti-inflammatory oral solution placed in the periodontal pocket after periodontal basic treatment, and the western medicine group had minocycline hydrochloride ointment placed in the periodontal pocket after periodontal basic treatment. The three treatment courses are all 4 weeks. Observe and compare three groups of periodontitis related indices, local signs, inflammatory factors, oxidative stress indicators, clinical efficacy, and adverse drug reactions.Results After treatment, the scores of periodontitis related indices, local signs, inflammatory factors, and other factors in the three groups were lower than before treatment(P<0.05); After treatment, the scores of the traditional Chinese medicine group and the western medicine group were significantly lower than those of the control group(P<0.05), while the scores of various indicators in the traditional Chinese medicine group were the lowest(P<0.05). After treatment, there were significant changes in oxidative stress indicators in each group compared to before treatment, and the difference was statistically significant(P<0.05), with the Chinese medicine group showing the most significant changes(P<0.05). After treatment, the clinical efficacy of the traditional Chinese medicine group(96.27%) was significantly higher than that of the Western medicine group(81.34%) and the control group(65.67%), and the difference was statistically significant(P<0.05). In terms of adverse reactions, the incidence rate of the traditional Chinese medicine group(0.75%) was significantly lower than that of the Western medicine group(11.19%)(P<0.05).Conclusion Pudilan anti-inflammatory oral liquid controlled-release drug strip has good therapeutic effect on chronic periodontitis with minimal side effects, and is worthy of promotion and application in oral clinical practice.更多还原