【摘要】 目的：评估食醋保留灌肠在肝性脑病患者治疗中的应用效果。方法：选取2022年8月—2024年7月钦州市第一人民医院收治的肝性脑病患者120例作为研究对象，以随机数字表法分为两组，每组60例。对照组接受食醋高位保留灌肠，观察组接受食醋渐插式保留灌肠。比较两组治疗效果。结果：相比于对照组，观察组治疗总有效率更高（P=0.015）。相比于对照组，观察组神志恢复时间更早（P<0.001）。治疗后，两组血氨、天冬氨酸氨基转氨酶、总胆红素水平降低，且观察组低于对照组（P<0.001）。两组不良反应总发生率比较，差异无统计学意义（P>0.05）。治疗后，两组生活质量综合评定问卷且评分提高，与对照组相比，观察组更高（P<0.001）。结论：相较于食醋高位保留灌肠，食醋渐插式保留灌肠在肝性脑病患者治疗中的应用效果更显著，不仅可促进患者意识状态恢复，还可降低血氨水平，改善肝功能，提高生活质量，但两种灌肠方式均有良好的治疗安全性。更多还原

【Abstract】 Objective: To evaluate the effect of vinegar retention enema in the treatment of patients with hepatic encephalopathy.Methods: A total of 120 patients with hepatic encephalopathy admitted to the First People’s Hospital of Qinzhou from August 2022 to July 2024 were selected as the study subjects. According to the random number table method, they were divided into two groups,with 60 cases in each group. The control group received vinegar high retention enema, and the observation group received vinegar gradual insertion retention enema. The therapeutic effects were compared between the two groups. Results: The overall response rate of treatment in the observation group was higher than that in the control group(P=0.015). The consciousness recovery time in the observation group was earlier than that in the control group(P<0.001). After treatment, the levels of blood ammonia, aspartate aminotransferase and total bilirubin in the two groups decreased, and the levels in the observation group were lower than those in the control group(P<0.001). There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05). After treatment, the scores of generic quality of life inventory in the two groups increased, and the score in the observation group was higher than that in the control group(P<0.001). Conclusion: Compared with vinegar high retention enema,vinegar gradual insertion retention enema has a significant effect in the treatment of hepatic encephalopathy, which can not only promote the recovery of consciousness, but also reduce the level of blood ammonia, improve liver function and quality of life.However, both enema methods have good treatment safety.更多还原