【摘要】 运动作为防治非酒精性脂肪肝的一线策略,具有多靶点、系统性获益的特点,通过协调多器官互作而非单一作用于肝脏,实现改善肝脂沉积且不加重代谢负担的独特优势,临床广泛应用于胰岛素抵抗、肥胖及相关代谢紊乱的防治。MAFLD作为一种多器官代谢网络失调性疾病,其发生发展与肝脏、脂肪、肌肉、肠道等器官功能紊乱密切相关,运动通过诱导多器官“对话”可有效逆转全身性代谢稳态失衡。基于其强大的多系统调控能力,运动已成为改善肝脏脂质代谢、抑制炎症反应、优化肠道微生态的核心干预手段。该文系统综述运动介导的多器官协同在MAFLD改善中的作用及机制,并对当前研究的局限性及未来方向进行展望。更多还原

【Abstract】 Exercise, as a first-line strategy for the prevention and treatment of non-alcoholic fatty liver disease, features multi-target and systemic benefits. By coordinating the interaction of multiple organs rather than acting solely on the liver, it has the unique advantage of improving hepatic lipid deposition without increasing the metabolic burden. It is widely used in clinical practice for the prevention and treatment of insulin resistance, obesity and related metabolic disorders. MAFLD, as a multi-organ metabolic network disorder disease, its occurrence and development are closely related to the functional disorders of organs such as the liver, fat, muscle and intestine. Exercise can effectively reverse the systemic metabolic homeostasis imbalance by inducing multiorgan “dialogue”. Due to its powerful multi-system regulatory capabilities, exercise has become a core intervention method for improving liver lipid metabolism, inhibiting inflammatory responses, and optimizing intestinal microecology. This article systematically reviews the role and mechanism of exercise-mediated multi-organ collaboration in the improvement of MAFLD, and looks forward to the limitations of current research and future directions.更多还原