【摘要】 细胞运动是生命体维持正常生理功能、应对外界环境变化以及参与组织发育和免疫反应等复杂过程的基础。而伪足作为细胞运动的关键结构,发挥着不可替代的核心作用。伪足是由细胞膜和细胞骨架动态重组形成的临时性突起,广泛存在于多种细胞类型中。它们通过延伸、感知和适应环境,从而参与细胞与基质的相互作用、信号转导以及吞噬等生物学过程。近年来,随着细胞生物学和分子生物学技术的进步,伪足的形成机制及其在细胞运动中的调控网络逐渐被揭示。该文将综述伪足的主要类型及功能、探讨细胞运动时伪足的复杂的分子调控网络,以及关于伪足数学模型构建的研究进展,为深入理解伪足的生物学功能及其在细胞运动研究中的应用提供重要参考。更多还原

【Abstract】 Cell motility is fundamental for organisms to maintain normal physiological functions, adapt to environmental changes, and participate in complex processes such as tissue development and immune responses. As a key structure in cell movement, pseudopodia plays an indispensable and central role. Pseudopodia are temporary protrusions formed by the dynamic reorganization of the cell membrane and cytoskeleton, and they are widely present in various cell types. By extending, sensing, and adapting to the environment, they participate in biological processes such as cell-matrix interactions, signal transduction, and phagocytosis. In recent years, with advances in cell biology and molecular biology techniques, the mechanisms underlying pseudopodia formation and their regulatory networks in cell motility have been gradually uncovered. This article reviews the major types and functions of pseudopodia, explores the complex molecular regulatory networks governing pseudopodia during cell movement, and discusses recent progress in mathematical modeling of pseudopodia. It provides important insights for a deeper understanding of the biological functions of pseudopodia and their applications in cell motility research.更多还原