【摘要】 植物细胞外囊泡(plant extracellular vesicles, PEVs)是由植物活细胞向外部环境分泌的一类被脂质膜包被的囊泡。这种囊泡包裹脂质、蛋白质、核酸等诸多生物信息分子,可作为治疗剂通过抑制肿瘤微环境,调控肿瘤代谢,抑制肿瘤增殖、转移,促进肿瘤细胞凋亡,抑制肿瘤血管生成,降低肿瘤耐药性,调节肠道菌群及抑制炎症反应等多种途径发挥抗肿瘤作用,也可作为药物载体递送小分子、核酸和蛋白质等抗肿瘤药物与其发挥协同治疗疾病的作用,提高抗肿瘤的治疗效果。该文阐明了PEVs的生物发生、分离方法及成分分析,重点总结了其作为药物和载体在肿瘤疾病中的研究进展,以期为PEVs在肿瘤疾病领域中的研究提供理论参考,推动其在肿瘤疾病治疗中的实际应用。更多还原

【Abstract】 PEVs(plant extracellular vesicles) are nanoscale bilayer vesicles spontaneously secreted by living plant cells. PEVs encapsulate lipids, proteins, nucleic acid and many other biological information molecules. It can be used as a therapeutic agent to play an anti-tumor role by inhibiting tumor microenvironment, regulating tumor metabolism, inhibiting tumor cell proliferation and metastasis, promoting tumor cell apoptosis, inhibiting angiogenesis of tumor cells, reducing drug resistance, regulating the intestinal flora and inhibiting inflammatory responses in various ways. It can also be used as a drug carrier to deliver small molecules, nucleic acids and proteins anti-tumor drugs to play a synergistic role in the treatment of tumor diseases and improve the therapeutic effect. In this paper, the biogenesis, separation methods and component analysis of PEVs, and the research progress of PEVs as drugs and carriers in tumor diseases are summarized in detail, in order to provide theoretical reference for the research of PEVs in the field of tumor diseases and promote its practical application in the treatment of tumor diseases.更多还原