【摘要】 目的 了解玉溪市2004-2021年报告丙型肝炎（简称丙肝）病例治疗情况，并分析后续治疗意愿。方法 对2004-2021年中国疾病预防控制信息系统中报告的现住址为玉溪市的丙肝病例进行问卷调查和HCV RNA测，分析治愈情况及未治疗和未治愈患者后续治疗意愿的影响因素。结果 3 474例丙肝报告病例中，未治疗2 003例（57.66%）,1 471例（42.34%）曾经治疗过，其中，1 114例（75.73%,1 114/1 471）治愈，357例（24.27%,357/1 471）未治愈。本次调查时，357例未治愈DBU丙肝患者298例（83.47%）有治疗意愿，多因素Logistic回归分析显示，未治愈丙肝患者中，相较于农民/民工患者，企业/事业单位/退休（OR=0.309,95%CI:0.113～0.846）、无业/待业（OR=0.266,95%CI:0.107～0.661）患者调查时有治疗意愿的可能性更低。2 003例未治疗过的丙肝患者有1 626例（81.17%）有治疗意愿，多因素Logistic回归分析显示，相较于在婚、收入>3 000元和丙肝知识知晓患者，离异/未婚/丧偶（OR=0.693,95%CI:0.536～0.895）、收入≤3 000元（OR=0.745,95%CI:0.562～0.988）和丙肝知识不知晓（OR=0.474,95%CI:0.377～0.597）的患者调查时有治疗意愿的可能性更低。结论 玉溪市报告丙肝病例既往治愈率较低，不同特征人群既往治愈率有差异，未治疗和未能治愈者进一步动员治疗时，应针对患者无治疗意愿的原因，加强丙肝知识以及丙肝治疗信息和相关政策宣传，提供社会性支持并进一步完善丙肝治疗救助政策。更多还原

【Abstract】 Objective To investigate the antiviral treatment of previously reported hepatitis C cases in Yuxi City from 2004 to 2021 and to understand the treatment willingness of untreated or uncured patients and its influencing factors. Methods A questionnaire survey and hepatitis C virus ribonucleic acid testing were conducted on hepatitis C cases reported in the China Disease Prevention and Control Information System from 2004 to 2021, with current residences registered as Yuxi City. The antiviral treatment status of patients and factors influencing the treatment willingness of untreated patients were analyzed. Results Among 3 474 reported hepatitis C cases, 2 003(57.66%) were untreated, while 1 471(42.34%) had received treatment. Of those treated, 1 114(75.73%, 1 114/1 471) were cured, and 357(24.27%, 357/1 471) remained uncured. At the time of this survey, 298(83.47%) of the 357 diagnosed but untreated(DBU) hepatitis C expressed treatment willingness. Multivariate logistic regression analysis revealed that among uncured patients with hepatitis C, compared to farmers/migrant workers, those enterprise/institution/retired individuals(OR=0.309, 95%CI: 0.113-0.846) and unemployed/waiting for employment(OR=0.266, 95%CI: 0.107-0.661) patients showed lower likelihood of treatment willingness during the survey. Among the 2, 003 untreated patients with hepatitis C, 1 626(81.17%) expressed willingness to undergo treatment. Multivariate logistic regression analysis indicated that compared to married patients, those with income >3 000 yuan and hepatitis C knowledge-aware patients, those divorced/unmarried/widowed(OR=0.693, 95%CI: 0.536-0.895), with income ≤3 000 yuan(OR=0.745, 95%CI: 0.562-0.988) and unaware of hepatitis C knowledge(OR=0.474, 95%CI: 0.377-0.597) demonstrated lower likelihood of treatment willingness during the survey. Conclusions Yuxi City has reported a relatively low historical cure rate for hepatitis C, with variations observed among different population groups. For those who were previously untreated or failed to achieve a cure, further mobilization for treatment should address the reasons behind the patients’ unwillingness to undergo therapy. This includes strengthening public awareness of hepatitis C, disseminating information on treatment options and relevant policies, providing social support, and improving hepatitis C treatment assistance policies.更多还原