【摘要】 目的 对艾滋病免疫重建不全研究领域进行文献计量学及可视化分析，以剖析研究重点和新兴趋势。方法 对Web of Science核心合集数据库中检索到的2000年之后艾滋病免疫重建不全相关研究的文献整理后，使用Citespace、VOSviewer等软件针对关键作者、时空分布、核心关键词、重要引文等信息进行可视化分析。结果 共有3 287篇纳入研究，在2000年至2013年间，年发文量总体呈现逐年稳步上升趋势，2014年后增势放缓，英国的伦敦大学发文量最多（219篇），我国首都医科大学在中心性方面排名第二（中心性值为0.09），本领域被引频次（1 833次）最高的文献是一篇临床实践指南，目前研究主要集中在机制探索、生物标志物开放和治疗策略优化，如T细胞功能异常及免疫激活与炎症、微生物群失调相关的致病机制，隐球菌性脑膜炎、结核病等机会性感染及共病风险等。结论 艾滋病免疫重建不全研究领域的前沿和焦点包括T细胞功能异常及免疫激活与炎症、微生物群失调相关的致病机制，隐球菌性脑膜炎、结核病等机会性感染及共病风险，预测INR的生物标志物探索，微生物组与恢复免疫重建的治疗手段。更多还原

【Abstract】 Objective To conduct a bibliometric and visual analysis of research on immunological non-responders in acquired immune deficiency syndrome(AIDS). This study aims to conduct a bibliometric and visual analysis of the research field concerning immunological non-responders in AIDS, in order to elucidate research focuses and emerging trends. Methods Literature related to immunological non-responders in AIDS published after 2000 was retrieved from the Web of Science Core Collection. Citespace and VOSviewer were employed for visual analysis of key authors, temporal and spatial distribution, core keywords, and significant citations. Results A total of 3 287 articles were included. From 2000 to 2013, the annual publication volume exhibited a steady increase;however, the growth rate slowed down after 2014.The University of London in UK had the highest output(219 publications), while China’s Capital Medical University ranked second in terms of centrality(centrality value of 0.09). The most frequently cited article(1 833 citations) was a clinical practice guideline. Current research primarily focuses on mechanistic exploration, biomarker discovery, and therapeutic optimization, such as the pathogenic mechanisms related to T cell dysfunction, immune activation and inflammation, microbiome-associated pathogenesis, opportunistic infections like cryptococcal meningitis and tuberculosis, and comorbidity risks. Conclusions The frontiers and research foci in the field of HIVassociated incomplete immune reconstitution include: pathogenic mechanisms related to T-cell dysfunction, immune activation and inflammation; microbial dysbiosis; opportunistic infections like cryptococcal meningitis and tuberculosis, and comorbidity risks; exploration of biomarkers for predicting immunological nonresponders;and microbiome-based therapeutic approaches for immune recovery.更多还原