【摘要】 目的 探讨晚期妊娠缩宫素引产成功的影响因素并对其分娩结局进行分析。方法 回顾性分析2021年1月—2024年1月吉林省妇幼保健院收治的289例有缩宫素引产指征的晚期妊娠初产妇临床相关资料，根据引产成功与否，将其分为成功组和失败组，采用多因素logistic回归分析缩宫素引产成功的影响因素。引产成功的产妇，根据产程中是否继续使用缩宫素分为继续滴注组和未继续滴注组，对比2组的分娩结局。结果247例引产成功纳入成功组，42例引产失败纳入失败组。成功组的年龄<30岁、羊水正常及首日有效宫缩4 h后宫颈Bishop评分改善≥3分的产妇占比分别为70.04%、71.26%、70.85%，高于对照组的45.24%、47.62%、45.24%，胎膜早破占比为7.29%，低于对照组的23.81%，差异均有统计学意义（P <0.05）。多因素logistic回归分析显示，年龄、羊水正常、胎膜早破及首日有效宫缩4 h后宫颈Bishop评分改善为晚期妊娠产妇缩宫素引产成功的独立影响因素（P <0.05）。引产成功的产妇中，125例继续滴注缩宫素的产妇纳入继续滴注组，122例未继续滴注缩宫素的产妇纳入未继续滴注组，2组分娩结局比较差异无统计学意义（P> 0.05）。结论 年龄、羊水正常、胎膜早破以及首日有效宫缩4h后Bishop评分改善是晚期妊娠产妇使用缩宫素引产成功的影响因素，在产妇临产之际，持续使用缩宫素，并不会对分娩结局产生显著影响。更多还原

【Abstract】 Objective To explore the influencing factors of successful induction of labor with oxytocin in late pregnancy and analyze its delivery outcomes. Methods A retrospective analysis was conducted on the clinical data of 289 primiparas with indications for oxytocin-induced labor in late pregnancy, who were treated at Jilin Women and Children Health Hospital from January 2021 to January 2024. These cases were divided into successful group and failed group based on the outcome of the induction.Multiple logistic regression analysis was used to identify the influencing factors of successful oxytocin-induced labor. Among the women who had successful inductions, they were further divided into two groups according to whether oxytocin was continued during the labor process: the continued infusion group and the non-continued infusion group. The delivery outcomes of the two groups were compared. Results A total of 247 cases of successful induction were included in the successful group, and 42 cases of failed induction were included in the failed group. In the successful group, the proportions of women who were aged < 30 years, had normal amniotic fluid, and had an improvement of ≥ 3 points in the cervical Bishop score 4 hours after the first effective uterine contractions on the first day were 70.04%, 71.26%, and 70.85%,respectively. These proportions were higher than those in the failed group(45.24%, 47.62%, and 45.24%, respectively). The proportion of women with premature rupture of membranes in the successful group was 7.29%, which was lower than that in the failed group(23.81%). The differences were statistically significant(P < 0.05).Multiple logistic regression analysis showed that age, normal amniotic fluid, premature rupture of membranes, and improvement in the cervical Bishop score 4 hours after the first effective uterine contractions on the first day were independent influencing factors for successful oxytocin-induced labor in late pregnancy(P < 0.05).Among the women who had successful induction, 125 women who continued oxytocin infusion were included in the continued infusion group, and 122 women who did not continue oxytocin infusion were included in the non-continued infusion group. There was no statistically significant difference in the obstetric outcomes between the two groups(P > 0.05). Conclusion Age, normal amniotic fluid, premature rupture of membranes, and improvement in the cervical Bishop score 4 hours after the first effective uterine contractions on the first day are the influencing factors for the successful induction of labor with oxytocin in late pregnancy.Continuous use of oxytocin during labor does not have a significant impact on the delivery outcome.更多还原