【摘要】 食管鳞状细胞癌（ESCC）患者预后差，肿瘤侵袭、转移是导致患者生活质量、生存率降低的主要原因。ESCC侵袭、转移涉及细胞外基质降解、上皮-间质转化（EMT）、肿瘤血管生成等多种机制，同时伴随多个层面的分子异常改变，如非编码RNA、EMT相关蛋白、基质金属蛋白酶、血管内皮生长因子、外泌体、循环肿瘤细胞等。预测ESCC侵袭、转移风险并采取积极的干预措施，是有效治疗ESCC、提高患者生活质量和生存率的关键。本研究就ESCC侵袭、转移相关分子标志物的研究进展作一综述，以期为ESCC的早诊、早治提供思路。更多还原

【Abstract】 Esophageal squamous cell carcinoma(ESCC) has a poor prognosis, and its invasion and metastasis are the main cause of decreased patients’ quality of life and survival rate. The invasion and metastasis of ESCC involve multiple mechanisms, including extracellular matrix degradation, epithelial-mesenchymal transition(EMT), and tumor angiogenesis, accompanied by molecular abnormalities at multiple levels, such as non-coding RNAs, EMT-related proteins, matrix metalloproteinases, vascular endothelial growth factor, exosomes, and circulating tumor cells. Predicting the risk of ESCC invasion and metastasis and implementing active interventions are crucial for effective treatment of ESCC and improvement of patients’ quality of life and survival rate. This article reviewed the research progress on molecular markers related to invasion and metastasis of ESCC, aiming to provide insights for the early diagnosis and treatment of ESCC.更多还原