【摘要】 多发性骨髓瘤（multiple myeloma, MM）的形成是一个涉及多种生物学因素和分子机制相互作用的复杂过程，与多种信号通路、肿瘤微环境（tumor micro-environment, TME）之间的相互作用密切相关。微小RNA(microRNA,miRNA)是一类高度稳定的小型非编码RNA,miR-28-3p作为其重要一员，通过诱导磷酸酶和张力蛋白同源基因（phosphatase and tensin homolog deleted on chromosome ten, PTEN）的表达及其他重要细胞因子的产生，在调控细胞增殖、凋亡、侵袭及转移等重要环节发挥其功能。本文结合国内外研究对miR-28-3p的作用机制进行综述，有助于阐明miR-28-3p在MM的发生、发展过程中发挥的重要作用及其分子机制，为其在MM的基因诊断、治疗靶标开发方面提供了新的理论依据和潜在靶点。更多还原

【Abstract】 The formation of multiple myeloma is a complex process involving the interaction of multiple biological factors and molecular mechanisms, which is closely related to the interaction between multiple signaling pathways and tumor micro-environment(TME). MicroRNA(miRNA) is a highly stable class of small non-coding RNAs. As an important member, miR-28-3p shows its characteristics in multiple myeloma by inducing the production of PTEN gene and other important cytokines, and regulates cell proliferation, apoptosis, invasion and metastasis. This article reviews the mechanism of action of miR-28-3p based on domestic and foreign studies, which is helpful to elucidate the important role played by miR-28-3p in the emergence and gradual development of multiple myeloma and the molecular mechanism behind it, and provides a new theoretical basis and potential targets for the genetic diagnosis and therapeutic target development of multiple myeloma.更多还原