【摘要】 目的 评估氨氯地平联合缬沙坦在老年原发性高血压合并糖尿病患者中的临床疗效，重点分析其在血压控制、糖代谢调节及肾功能保护方面的应用价值。方法 回顾性选取2022年9月—2024年7月福建省漳州市医院收治的240例老年原发性高血压合并糖尿病患者的临床资料，根据不同治疗方法分为单药组（122例）、联合组（118例）。两组均进行降糖治疗，单药组接受氨氯地平单药治疗，联合用药组接受氨氯地平联合缬沙坦治疗。比较两组血压水平、胰岛素抵抗水平、不良反应。结果 治疗后，联合组收缩压、舒张压水平均低于单药组，差异均有统计学意义（P均<0.05）。治疗后，联合组空腹血糖、餐后2 h血糖、甘油三酯-葡萄糖指数、糖化血红蛋白水平均低于单药组，差异均有统计学意义（P均<0.05）。联合组患者不良反应发生率与单药组比较，差异无统计学意义（P>0.05）。结论 在老年原发性高血压合并糖尿病患者中，氨氯地平联合缬沙坦较氨氯地平单药治疗降压效果更佳，能改善糖代谢，且安全性良好。更多还原

【Abstract】 Objective To evaluate the clinical efficacy of amlodipine combined with valsartan in elderly patients with essential hypertension and diabetes, and to analyze its application value in blood pressure control, glucose metabolism regulation and renal function protection. Methods The clinical data of 240 elderly patients with essential hypertension and diabetes admitted to Zhangzhou Municipal Hospital of Fujian Province from September 2022 to July 2024 were retrospectively selected. According to different treatment methods, they were divided into single drug group(122 cases) and combined group(118 cases). Both groups were treated with hypoglycemic therapy. The single drug group received amlodipine monotherapy, and the combined drug group received amlodipine combined with valsartan. The blood pressure level, insulin resistance level and adverse reactions were compared between the two groups. Results After treatment, the levels of systolic blood pressure and diastolic blood pressure in the combined group were lower than those in the single drug group, and the differences were statistically significant(both P<0.05). After treatment, the levels of fasting plasma glucose, 2-hour postprandial plasma glucose, triglyceride-glucose index and glycated hemoglobin A1c in the combined group were lower than those in the single drug group, and the differences were statistically significant(all P<0.05). There was no significant difference in the incidence of adverse reactions between the combined group and the single drug group(P>0.05). Conclusion In elderly patients with essential hypertension and diabetes, amlodipine combined with valsartan has better antihypertensive effect than amlodipine monotherapy, can improve glucose metabolism, and has good safety.更多还原