【摘要】 目的 评估低砷暴露地区儿童各形态砷的内暴露水平，并分析其影响因素。方法 选取华中地区武汉和华南地区深圳共130名0～7岁儿童的390份尿样，利用高效液相色谱-电感耦合等离子体质谱联用技术测定尿中各形态砷水平，采用线性混合模型分析砷的内暴露水平的影响因素，并基于生物监测当量对儿童尿中砷浓度进行风险评估。结果儿童尿总砷平均水平为13.6μg/L,除砷酸盐(As~Ⅴ)外，各形态砷的浓度随年龄增长上升。深圳儿童尿液中砷甜菜碱(AsB)浓度高于武汉儿童(P<0.05),一甲基砷酸(MMA)和二甲基砷酸(DMA)浓度在冬季采样中显著高于秋季(均P<0.05)。72%的儿童尿砷浓度高于已有文献报道的生物监测当量。结论 儿童尿砷水平随年龄增加而呈上升趋势，且存在地域和季节差异。研究人群中有半数以上儿童的尿砷水平提示存在潜在健康风险，需进一步监测和加强防控措施。更多还原

【Abstract】 Objective To investigate internal arsenic exposure levels and influencing factors in infants and young children from low-arsenic regions.Methods A total of 390 urine samples from 130 children aged 0-7 years in Wuhan(central China)and Shenzhen(southern China)were analyzed using high performance liquid chromatography-inductively coupled plasma mass spectrometry.A linear mixed model was applied to assess factors influencing arsenic exposure levels, and risk evaluation was conducted based on biomonitoring equivalents.Results The average urinary total arsenic level in children was 15.6 μg/L.The concentrations of these species increased with age, except for arsenate(As~Ⅴ).Children in Shenzhen had higher level of arsenobetaine(AsB) than in Wuhan(P<0.05).The urinary levels of monomethyl arsenic acid(MMA)and dimethyl arsenic acid(DMA) were significantly higher in winter than in autumn(P<0.05).Total urinary arsenic levels in 72% of the children exceeded the biomonitoring equivalent.Conclusion Arsenic exposure among children shows an increasing trend with age, and there are regional and seasonal differences.More than half of the children may suffer potential health risks of As exposure, highlighting the urgent need for improved monitoring and preventive measures.更多还原