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有氧糖酵解在糖尿病肾病中的作用研究进展

Research Advances on the Role of Aerobic Glycolysis in Diabetic Kidney Disease

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【作者】 扈晓芳; 欧阳沙西;

【Author】 Hu Xiaofang;Ouyang Shaxi;Hunan Normal University Health Science Center;Department of Nephrology,Hunan Provincial People’s Hospital,the First Affiliated Hospital of Hunan Normal University;

【通讯作者】 欧阳沙西;

【机构】 湖南师范大学医学部; 湖南省人民医院(湖南师范大学附属第一医院)肾内科;

【摘要】 糖尿病肾病(DKD)是糖尿病患者常见的并发症之一,严重影响患者的生活质量和预后。有氧糖酵解作为细胞代谢的重要途径,在调节肾脏功能、细胞生存及应激反应中发挥着关键作用。近年来,越来越多的研究表明,有氧糖酵解在糖尿病肾病的发病机制、进展及治疗中扮演了重要角色。该文综述了有氧糖酵解在糖尿病肾病中的最新研究进展,从细胞代谢的角度探讨其对糖尿病肾病的影响及潜在的治疗靶点。

【Abstract】 Diabetic kidney disease is one of the common complications in diabetic patients, significantly affecting their quality of life and prognosis.Aerobic glycolysis, an important metabolic pathway, plays a critical role in regulating kidney function, cell survival, and stress responses.In recent years, an increasing number of studies have highlighted the significant role of aerobic glycolysis in the pathogenesis, progression, and treatment of diabetic kidney disease.This article aims to review the latest research advancements related to aerobic glycolysis in diabetic kidney disease, exploring its impact on the disease and potential therapeutic targets from the perspective of cellular metabolism.

【基金】 湖南省自然科学基金资助项目(No.2024JJ9280)
  • 【文献出处】 华中科技大学学报(医学版) ,Acta Medicinae Universitatis Scientiae et Technologiae Huazhong , 编辑部邮箱 ,2025年04期
  • 【分类号】R692.9;R587.2
  • 【下载频次】92
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