【摘要】 目前针对急性肾损伤(acute kidney injury, AKI)的有效治疗措施匮乏，临床上对该病的治疗常以缓解症状为目标。血小板作为血液循环中重要的组成部分，具有数目众多且作用广泛的特点。在AKI肾脏内发现存在血小板浸润，可能与P-选择素(P-selectin)、RANTES、整合素αⅡbβ3等血小板活化相关分子表达水平增高有关，说明AKI中血小板存在活化，可能对肾脏病程存在潜在影响。此外，目前一些临床研究和动物模型研究初步表明，抗血小板治疗可以在多种因素引起的AKI中缓解组织损伤并保护肾功能。该文通过对现有研究的总结，一方面阐明血小板在AKI病理生理变化中的作用及具体机制；另一方面探讨抗血小板治疗在AKI中的应用前景，以期对AKI的诊疗提供新的靶点和方法。更多还原

【Abstract】 Currently, there is a paucity of efficacious treatments for acute kidney injury(AKI),and existing therapeutic approaches primarily aim to mitigate symptoms and enhance patient outcomes.Platelets, a vital element of the circulatory system, are characterized by their abundance and multifaceted functions.Moreover, several studies have documented platelet infiltration within the kidneys during AKI,revealing elevated expression levels of platelet activation markers such as P-selectin, RANTES,and integrin αⅡbβ3.This suggests that platelet activation occurs in AKI and may influence the progression of the disease.Furthermore, preliminary findings from both clinical and animal model studies indicate that antiplatelet therapy could reduce tissue damage and protect renal function in AKI resulting from various etiologies.This review aims to elucidate the role of platelets in the pathophysiology of AKI by synthesizing current researches, while also investigating the potential of antiplatelet therapy as a novel approach for the management of AKI,thereby offering new diagnostic and therapeutic strategies.更多还原