【摘要】 在脓毒性休克的治疗中，去甲肾上腺素作为推荐的首选升压药物用于纠正低血压，然而大剂量应用会显著增加儿茶酚胺相关不良反应事件的发生风险。采用去甲肾上腺素联合数种非儿茶酚胺类血管活性药物的多模式治疗策略，可有效降低去甲肾上腺素的使用剂量，进而减轻与大剂量儿茶酚胺需求相关的潜在药物不良影响。本文基于脓毒性休克的病理生理学机制、儿茶酚胺类药物在脓毒性休克中的应用现状，以及血管活性药物多模式治疗策略的研究进展进行综述。更多还原

【Abstract】 Norepinephrine is recommended as the first-line vasopressor for treating hypotension in septic shock, but high-dose norepinephrine significantly increases catecholamine-related adverse events. Studies have confirmed that a multimodal therapeutic strategy of norepinephrine in combination with several non-adrenergic vasopressors in septic shock has the ability to reduce the dose of norepinephrine and attenuate the potential adverse drug events associated with high-dose adrenergic vasopressors requirements. In this article, we present a review of research progress related to the pathophysiological mechanisms of septic shock, the application of adrenergic vasopressor drug in septic shock, and multimodal treatment strategy for the use of vasopressors drug combinations in septic shock.更多还原