【摘要】 目的 探讨杭州地区单采血小板献血者炎症相关因子C反应蛋白（CRP）、淀粉样蛋白A(SAA)、白细胞计数（WBC）、中性粒细胞计数（NE）水平。方法 收集884例在浙江省血液中心（2023年11—12月）单采血小板献血者人群作为研究对象，按照性别、年龄、献血次数进行分组。所有献血者均进行CRP、SAA、WBC、NE水平检测，回顾性分析比较不同年龄、性别、献血次数献血者CRP、SAA、WBC、NE水平。结果 献血者年龄越大（按18～30岁，31～40岁，41～50岁，51～60岁分组），CRP[(4.32±1.26)mg/L,(4.81±1.29)mg/L,(5.25±1.31)mg/L,(5.28±1.33)mg/L]、SAA [(2.90±0.37)mg/L,(3.10±0.38)mg/L,(3.39±0.39)mg/L,(3.57±0.41)mg/L]、NE[(57.80±5.62)%,(59.45±5.66)%,(60.46±5.68)%,(62.20±5.69)%]水平越高（t=26.937,104.391,16.680,P<0.001），而41～60岁献血者CRP[(5.25±1.31),(5.28±1.33)mg/L]水平及不同年龄段献血者WBC[(6.09±1.86)×109/L,(6.12±1.89)×109/L,(5.80±1.81)×109/L,(6.02±1.92)×109/L]水平相比差异无统计学意义（t=0.167,1.481,P>0.05）。男性献血者CRP[(5.01±1.29)mg/L]水平高于女性[（4.02±1.21）mg/L],SAA[(3.04±0.37)mg/L]、NE[(59.01±5.63)%]水平低于女性[（3.51±0.39）mg/L,(60.52±5.67)%(t=9.643,-15.554,-3.319,P<0.05)，而男性[（5.97±1.81）×109/L]、女性[（6.18±1.88）×109/L]献血者WBC水平相比差异无统计学意义（t=-1.426,P>0.05）。献血次数≤100次献血者CRP[(4.75±1.24)mg/L]、SAA[(3.05±0.36)mg/L]、NE[(59.05±5.64)%]水平低于献血次数>100次[（5.08±1.29）mg/L,(3.93±0.41) mg/L,(61.76±5.67)%]献血者，WBC[(6.06±1.84)×109/L]水平高于献血次数>100次[（5.65±1.78）×109/L]献血者（t=-3.269,-29.343,-5.949,2.782,P<0.05）。结论 杭州地区单采血小板年龄较高者，其机体炎症相关因子CRP、SAA、NE水平较高，且男性献血者CRP水平较女性高，SAA、NE水平较女性低，献血次数高于100次者炎症相关因子CRP、SAA、NE水平较高，但在厂家试剂检测标准参考区间范围以内，WBC水平较低，而WBC水平不受年龄和性别影响，献血前检查过程中可根据不同年龄、性别、献血次数患者着重检查炎性因子水平，达到保证献血质量目的。更多还原

【Abstract】 Objective To investigate the levels of CRP, SAA, WBC and NE of platelet donors in Hangzhou area. Methods A population of 884 single-collected platelet donors at the Zhejiang Blood Centre(November 2023 to December 2023) was collected as study subjects and grouped according to gender, age and number of times of blood donation. All donors were tested for CRP, SAA, WBC, and NE levels, and retrospective analyses were performed to compare CRP, SAA, WBC, and NE levels in donors of different ages, genders, and numbers of blood donations. Results The older the age of the donors(18～30, 31～40, 41～50, 51～60 years old)the higher the CRP [(4.32±1.26)mg/L,(4.81±1.29)mg/L,(5.25±1.31)mg/L,(5.28±1.33) mg/L], SAA [(2.90±0.37)mg/L,(3.10 ±0.38)mg/L,(3.39 ±0.39)mg/L,(3.57 ±0.41) mg/L], NE [( 57.80 ±5.62)%,(59.45 ±5.66)%,(60.46 ±5.68)%,(62.20±5.69)%] levels were higher(t=26.937, 104.391, 16.680, P<0.001), whereas in 41～50 years old and 51～60year old blood donors CRP [(5.25±1.31)mg/L,(5.28±1.33) mg/L] levels and WBC [(6.09±1.86)×109/L,(6.12±1.89)×109/L,(5.80 ±1.81) ×109/L,(6.02 ±1.92) × 109/L] levels in blood donors aged 18 ～60 years were not statistically different compared to those of male blood donors(t=0.167, 1.481, P>0.05). CRP [(5.01±1.29) mg/L] levels were higher in male than female [(4.02 ±1.21) mg/L] blood donors and SAA [(3.04 ±0.37) mg/L], NE [(59.01 ±5.63)% ] levels were lower than in female [(3.51±0.39) mg/L,(60.52±5.67)%] blood donors(t=9.643,-15.554,-3.319, P<0.05), whereas there was no statistically significant difference in the WBC levels of male [(5.97 ±1.81)×109/L] and female [(6.18 ±1.88) ×109/L] donors compared to the WBC levels of male [(5.97 ±1.81) ×109/L] and female [(6.18 ±1.88)×109/L] donors(t=-1.426, P<0.05). The levels of CRP [(4.75±1.24) mg/L], SAA [(3.05±0.36) mg/L], and NE[(59.05±5.64)%] were lower in donors with ≤100 blood donations than in donors with 100 blood donations [(5.08±1.29)mg/L,(3.93±0.41)mg/L,(61.76±5.67)%] blood donors, and WBC [(6.06±1.84)×109/L] levels were higher than those of blood donors with >100 donations [(5.65 ±1.78) ×109/L](t =-3.269,-29.343,-5.949, 2.782, P <0.05).Conclusion In Hangzhou area, patients with older age of platelet collection had higher levels of inflammation-related factors CRP, SAA and NE; male blood donors had higher levels of CRP and lower levels of SAA and NE than female blood donors; those who donated blood more than 100 times had higher levels of inflammation-related factors CRP, SAA and NE, but they were within the reference range of the manufacturer’ s reagent detection standard. The level of WBC is low, and the level of WBC is not affected by age and gender. In the process of pre-blood donation examination, the level of inflammatory factors can be examined according to different age, gender and number of blood donations, so as to ensure the quality of blood donation.更多还原